Status of Histoid Leprosy — A Clinical, Bacteriological, Histopathological and Immunological Appraisal —

Abstract

The study of different aspects, namely clinical, bacteriological, histopathological and immunological, of 23 cases of histoid leprosy were quite revealing. The salient features included the occurrence of histoid lesions in a proportion of untreated leprosy patients in addition to those on dapsone treatment for a variable periods of time, a high bacteriological index in spite of infrequent formation of globi, high morphological indices and the immunological status of these patients. Cell‐mediated immunity, which was deficient in relation to healthy controls, appeared to be augmented when compared with active lepromatous (LL) patients. A few contributory factors to the development of such a situation are discussed.

Histoid leprosy: a retrospective study of 40 cases from India

“…9 The term 'histoid leprosy' was first coined by Wade in 1960 as a histological concept of bacillary rich leproma composed of spindle-shaped cells along with an absence of globus formation. 3 Since then few case series have been published, mostly from India.…”

Histoid Leprosy: A Prospective Diagnostic Study in 38 Patients

“…Unfortunately, very few endeavours have been made to conceive it as a clinical entity [8,9]. In the process, several investigations of the past had continued to thrive on the original concepts o f Wade [2] that this entity should be diagnosed only on retrospective evaluation of histopathology [3], We con sider it totally unwarranted.…”

“…However, in our experience [6][7][8][9], it can be diagnosed with certainty relying on its prospective clinical features, a fact succinct ly illustrated in our communication.…”

A Retrospective Study on Histoid Hansen’s Disease - An Insight Into Aetiopathogenesis and Disease Pattern

“…Sehgal and Srivastava and Kalla et al described a Type 2 reaction only in one out of 23 and 2 out of 25 patients with Histoid Leprosy respectively. (11,12) Type 2 reactions can also develop after initiation of MDT (Multi-Drug Therapy) for leprosy. (13) Type I reactions are reported very rarely in Histoid Hansen, (14) usually commencing 10 weeks after Multi-Bacillary Multi-Drug Therapy.…”