“…Tiagabine Increases MC Seizures before GTC Seizures. Tiagabine has been associated with MC seizures or absence status epilepticus in rodent models of generalized epilepsy (Coenen et al, 1995;Hosford and Wang, 1997;Lancel et al, 1998), in individuals with epilepsy (Eckardt and Steinhoff, 1998;Ettinger et al, 1999;Mangano et al, 2003;Skardoutsou et al, 2003;Koepp et al, 2005), and in nonepileptic individuals in overdose (Zhu and Vaughn, 2002;Leikin et al, 2008). In DS mice, we observed a substantial, dose-dependent increase in the number of MC seizures before the first GTC seizure with TGB (Fig.…”