Status Epilepticus Associated with Borage Oil Ingestion

Al-Khamees, Wafa’a A.; Schwartz, Michael D.; Alrashdi, Saleh; Algren, Adam D.; Morgan, Brent

doi:10.1007/s13181-011-0135-9

Cited by 19 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pleiotropic activities with beneficial effects have been attributed to borage seed oil for the treatment of several disorders such as acute respiratory distress syndrome, rheumatoid arthritis, diabetic neuropathy, menopause and atopic dermatitis [3]–[5]. Here, we present the first study showing results regarding the toxicity, genotoxicity, antigenotoxicity and longevity properties, of borage seed oil along with one of its active components (GLA).…”

Section: Discussionmentioning

confidence: 97%

“…This unusual fatty acid is an intermediate of indispensable compounds in the body such as prostaglandin E1 and its derivatives [1]. Borage seed oil has been promoted as an effective treatment for different pathologies, such as acute respiratory distress syndrome [2], [3], rheumatoid arthritis [4], atopic dermatitis, diabetic neuropathy and menopause-related symptoms [5]. It has also been shown to decrease inflammation, improve bone health [6] and exhibit beneficial effects on the function of the skin [7] and on the regulation of lipid metabolism [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies

et al. 2013

View full text Add to dashboard Cite

Borage (Borago officinalis L.) seed oil has been used as a treatment for various degenerative diseases. Many useful properties of this oil are attributed to its high gamma linolenic acid content (GLA, 18:3 ω-6). The purpose of this study was to demonstrate the safety and suitability of the use of borage seed oil, along with one of its active components, GLA, with respect to DNA integrity, and to establish possible in vivo toxic and in vitro cytotoxic effects. In order to measure these properties, five types of assays were carried out: toxicity, genotoxicity, antigenotoxicity, cytotoxicity (using the promyelocytic leukaemia HL60 cell line), and life span (in vivo analysis using the Drosophila model). Results showed that i) Borage seed oil is not toxic to D. melanogaster at physiological concentrations below 125 µl/ml and the studies on GLA indicated non-toxicity at the lowest concentration analyzed ii) Borage seed oil and GLA are DNA safe (non-genotoxic) and antimutagenic compared to hydrogen peroxide, thereby confirming its antioxidant capacity; iii) Borage seed oil and GLA exhibited cytotoxic activity in low doses (IC50 of 1 µl/ml and 0.087 mM, respectively) iv) Low doses of borage seed oil (0.19%) increased the health span of D. melanogaster; and v) GLA significantly decreased the life span of D. melanogaster.Based on the antimutagenic and cytotoxic effects along with the ability to increase the health span, we propose supplementation with borage seed oil rather than GLA, because it protects DNA by modulating oxidative genetic damage in D. melanogaster, increases the health span and exerts cytotoxic activity towards promyelocytic HL60 cells.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies

et al. 2013

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, specific tests of the liver function after ingestion of blackcurrant seed oil have not been performed thus far in either human or animal studies. However, there is a case study by Al-Khamees et al [ 33 ] where the adverse effects of a γ-linolenic acid-rich borage oil have been described, including elevated transaminase levels. According to the available guidelines for preclinical studies, a two times or higher increase in plasma ALT activity should raise concerns on the hepatocellular injury [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet

2014

View full text Add to dashboard Cite

PurposeIt was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine.MethodsMale Wistar rats were randomly assigned to four groups of eight animals each and were fed a basal or obesogenic (high in fat and low in fibre) diet that contained either rapeseed oil (Canola) or blackcurrant seed oil. A two-way analysis of variance was then applied to assess the effects of diet and oil and the interaction between them.ResultsAfter 8 weeks, the obesogenic dietary regimen increased the body weight, altered the plasma lipid profile and increased the liver fat content and the plasma transaminase activities. In addition, the obesogenic diet decreased bacterial glycolytic activity and short-chain fatty acid formation in the distal intestine. Dietary blackcurrant seed oil improved the lipid metabolism by lowering liver fat accumulation and the plasma triglyceride concentration and atherogenicity as well by increasing the plasma HDL-cholesterol concentration. However, in rats fed an obesogenic diet containing blackcurrant seed oil, the plasma HDL-cholesterol concentration was comparable with both rapeseed oil-containing diets, and a significant elevation of the plasma transaminase activities was noted instead.ConclusionsThe obesogenic dietary regimen causes a number of metabolic disorders, including alterations in the hindgut microbial metabolism. Dietary blackcurrant seed oil ameliorates the lipid metabolism; however, the beneficial effect is restricted when it is provided together with the obesogenic diet, and a risk of liver injury may occur.

show abstract

“…Borage oil used for AD treatment was proposed on a hypothesis that patients with AD generally suffer from metabolic aberration of linoleic acid to gamma-linolenic acid (GLA) caused by inactivation of the delta-6 desaturase enzyme [40,41]. Borage oil has been extensively studied as a complementary therapy in AD treatment due to its abundant content of GLA [42][43][44]. Kanehara and co-workers developed a borage oil-coated fabric and examined its clinical efficacy in AD treatment [30].…”

Section: Healthcare Textilesmentioning

confidence: 99%

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

2017

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterized by intense puritus and skin dryness. The pathogenesis for AD has not been fully understood to date. Complementary therapies are very popular as effective treatment for AD among clinical practitioners. This study presents a comprehensive review of published works associated with textiles-based complementary therapies for AD treatment such as wet-wrap dressing, functionalized textiles, and the application of hydrogel techniques in the textile industry to provide a better understanding of the development and design of new textiles-based transdermal therapies.

show abstract

Status Epilepticus Associated with Borage Oil Ingestion

Cited by 19 publications

References 18 publications

Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies

Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies

Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

Contact Info

Product

Resources

About