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The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

Wetness sensation is a crucial factor affecting wear comfort. In this study, a measurement method that is capable of characterizing the subjective wetness sensation of various textile products, such as sportswear, leisurewear, uniforms and health-care products, was developed. A subjective rating scale was adopted for response measurement and 20 different fabrics varying in fiber composition, yarn type and fabric structure were evaluated by 22 subjects. The testing procedure was standardized, ensuring within-subject reliability and between-subject consistency. This method also displays high sensitivity and the result is rational with barely to slightly wet sensation for the absorbing fabrics and very wet feeling for the hydrophobic ones. In addition, an objective measurement method for evaluating the horizontal wicking area of fabrics utilizing the image analysis technique was developed. Using conventional testing instruments, such as the Gravimetric Absorbency Testing System, Moisture Management Tester, international standard testing methods and the proposed horizontal wicking tester, various objective water absorption and transport properties were measured and their correlation with the subjective wetness rating was studied. Horizontal wicking area and water absorption capacity of fabrics were found to have strong correlation with subjective wetness sensation.

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Bio-inspired engineering has been envisioned in a wide array of applications. All living bodies on Earth, including animals and plants, have well organized functional systems developed by nature. These naturally designed functional systems inspire scientists and engineers worldwide to mimic the system for practical applications by human beings. Researchers in the academic world and industries have been trying, for hundreds of years, to demonstrate how these natural phenomena could be translated into the real world to save lives, money and time. One of the most fascinating natural phenomena is the resistance of living bodies to contamination by dust and other pollutants, thus termed as self-cleaning phenomenon. This phenomenon has been observed in many plants, animals and insects and is termed as the Lotus Effect. With advancement in research and technology, attention has been given to the exploration of the underlying mechanisms of water repellency and self-cleaning. As a result, various concepts have been developed including Young’s equation, and Wenzel and Cassie–Baxter theories. The more we unravel this process, the more we get access to its implications and applications. A similar pursuit is emphasized in this review to explain the fundamental principles, mechanisms, past experimental approaches and ongoing research in the development of bio-inspired superhydrophobic textiles.

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