Statistical calculation of the transition of vitamin a and β-carotene ingestion in the former West and East German regions between 1986 and 1993

Gericke, Janine; Aydemir, Gamze; Ulbricht, G.; Rühl, Ralph

doi:10.1556/aalim.39.2010.3.11

Cited by 2 publications

(4 citation statements)

References 30 publications

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“…Fortunately, we can also partly compare and draw conclusions between the populations of former West Germany and East Germany, which possess a comparable genetic background, but in the East Germans a lower socioeconomic background and different lifestyle and nutritional behavior [92,155,156,157]. Children in the former East Germany had a lower atopy prevalence than their West German counterparts [158,159,160].…”

Section: Ethnicity Atopy and Nutritionmentioning

confidence: 99%

“…Children in the former East Germany had a lower atopy prevalence than their West German counterparts [158,159,160]. The general food intake of West versus East Germans was different in many aspects; these facts, mainly related to PUFA and vitamin intake, have been reported (table 3) [92]. …”

Section: Ethnicity Atopy and Nutritionmentioning

confidence: 99%

“…In the Western diet, various nutrients are present in high concentrations like sugar, fat, n6-PUFAs, vitamin A and pro-vitamin A carotenoids (table 3) [40,91,92], while other nutrients like n3-PUFAs and non-pro-vitamin A carotenoids are less abundant [40]. Carotenoids are the nutritional biomarkers of consumed foods that contain them in high concentrations [7,20].…”

Section: Introductionmentioning

confidence: 99%

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Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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Carotenoids are important derivatives of the human diet and occur in high concentrations in the human organism. Various carotenoids are also present in human breast milk and are transferred to breast-fed children. The alternative to breastfeeding is supplementation with an infant milk formula, but these formulas contain only a limited variety of carotenoids. Our question is: ‘What is the function of various carotenoids in human nutrition with a special emphasis on child development and the development of atopy?’ In this review, the mechanisms of action of the most important non-pro-vitamin A and pro-vitamin A carotenoids: α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene and retinoids are discussed. In summary, the combination of carotenoids, especially lycopene, seems to be of great importance, and exclusive usage of β-carotene in infant formula may yield in an increased atopy prevalence mediated in various target organs like the skin, lungs and immune competent cells. We conclude that the determination of novel bioactive metabolites of various carotenoids, at various stages in different organs during atopy development, might be the key to understanding the potential importance of carotenoids on atopy development.

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Section: Ethnicity Atopy and Nutritionmentioning

confidence: 99%

Section: Ethnicity Atopy and Nutritionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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“…Vitamins A and D and their derivatives regulate multiple key physiological processes in the skin including apoptosis [1, 2], immune function [3-5] and normal epidermal homeostasis [6-9]. Retinoids and provitamin A carotenoids have been shown to be involved and altered in atopic diseases [2, 3, 10-17].…”

Section: Introductionmentioning

confidence: 99%

Topical Vitamin D Receptor Antagonist/Partial-Agonist Treatment Induces Epidermal Hyperproliferation via RARγ Signaling Pathways

et al. 2020

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Vitamin D and A derivatives are well-known endogenous substances responsible for skin homeostasis. In this study we topically treated shaved mouse skin with a vitamin D agonist (MC903) or vitamin D antagonist/partial agonist (ZK159222) and compared the changes with acetone (control treatment) treatment for 14 days. Topical treatment with ZK159222 resulted in increased expression of genes involved in retinoic acid synthesis, increased retinoic acid concentrations and increased expression of retinoid target genes. Clustering the altered genes revealed that heparin-binding epidermal growth factor-like growth factor, the main driver of epidermal hyperproliferation, was increased via RARγ-mediated pathways, while other clusters of genes were mainly decreased which were comparable to the changes seen upon activation of the RARα-mediated pathways. In summary, we conclude that epidermal hyperproliferation of mouse skin in response to a topically administered vitamin D receptor antagonist/partial agonist (ZK159222) is induced via increased retinoic acid synthesis, retinoic acid levels and increased RARγ-mediated pathways.

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Statistical calculation of the transition of vitamin a and β-carotene ingestion in the former West and East German regions between 1986 and 1993

Cited by 2 publications

References 30 publications

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Topical Vitamin D Receptor Antagonist/Partial-Agonist Treatment Induces Epidermal Hyperproliferation via RARγ Signaling Pathways

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