State‐of‐the‐art applications of cyclodextrins as functional monomers in molecular imprinting techniques: a review

Abstract

As a versatile tool in separation science, cyclodextrins and their derivatives, known as emerging functional monomers, have been used extensively in molecular imprinting techniques. The attributes of cyclodextrins and their derivatives are widely known to form host-guest inclusion complex processes between the polymer and template. The exploitation of the imprinting technique could produce a product of molecularly imprinted polymers, which are very robust with long-term stability, reliability, cost-efficiency, and selectivity. Hence, molecularly imprinted polymers have gained popularity in chemical separation and analysis. Molecularly imprinted polymers containing either cyclodextrin or its derivatives demonstrate superior binding effects for a target molecule. As noted in the previous studies, the functional monomers of cyclodextrins and their derivatives have been used in molecular imprinting for selective separation with a wide range of chemical compounds, including steroidals, amino acids, polysaccharides, drugs, plant hormones, proteins, pesticides, and plastic additives. Therefore, the main goal of this review is to illustrate the exotic applications of imprinting techniques employing cyclodextrins and their derivatives as single or binary functional monomers in synthesizing molecularly imprinted polymers in areas of separation science by reviewing some of the latest studies reported in the literature.

Synthesis and application of selective adsorbent for pirimicarb pesticides in aqueous media using allyl‐β‐cyclodextrin based binary functional monomers

“…β ‐Cyclodextrin ( β ‐CD) and its derivatives are typically synthesised as either a single or binary functional monomer, and MIPs containing either cyclodextrin or its derivatives demonstrated superior binding effects for a target molecule. The application of adsorbents containing cyclodextrins in separation science has been reviewed …”

“…The application of adsorbents containing cyclodextrins in separation science has been reviewed. 9 Recently, several newly developed methods of detection and determination of trace levels of pirimicarb have been reported; [10][11][12][13] individuals claimed their own advantages of their innovative analytical methods. However, there is still a great need for an alternative simpler and efficient method of detection and quantification of trace amounts of analyte.…”

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

“…Interestingly, Su et al [47] used computer-assisted molecular simulation calculations to select the suitable functional monomer and solvent for the template molecule. MAA is reported as the functional monomer which can form desirable pore shape and structure [48], meanwhile, it can be hydrogen bond based acceptor and donor [49]. Other monomers used in MIPs/SIPs synthesis include sulphonic acids (e.g., 2-acrylamido-2-methylpropane sulphonic acid), carboxylic acids (e.g., acrylic acid, vinylbenzoic acid), and heteroaromatic bases (e.g., vinylpyridine, vinylimidazole) were summarized by Choi and coworkers [33].…”

Synthesis of core‐shell magnetic molecularly imprinted polymer for the selective determination of imidacloprid in apple samples

“…The superior properties of MIPs include their high selectivity and sensitivity, low cost, physicochemical stability and reusability, which make them highly attractive materials . Currently, magnetic molecularly imprinted polymers (MMIPs) are attracting attention due to their versatility , specific and rapid magnetic separation ability , which allows the use of an external magnet to avoid centrifugation and filtration , good dispersion properties , high selectivity and sensitivity, and reusability . MMIPs have already been reported for imidacloprid detection ; however, the selectivity and sensitivity of MMIPs can be improved with different modification methods to achieve good results in complex matrix samples.…”