Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Abstract

Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

“…This technology appears in and is supported by their previously published work for dengue, yellow fever, and Ebola viruses (Yen et al, 2015). Our previous work discussed the Molecularly Imprinted Polymers (MIPs) and Surface Imprinted Polymers (SIPs)-based electrochemical biosensor for virus antigen detection (Cui et al, 2020). However, there are still few published articles for detection of the whole SARS-CoV-2 virus or their antigens.…”

Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells

“…Numerous papers have reported the studies of electrochemical techniques for detecting small biomolecules as an early diagnosis [ 26 ]. The electrochemical detection of DNA and RNA has been used to diagnose viral infections, such as coronavirus, Zika virus, and hepatitis E [ 57 , 58 , 59 , 60 , 61 ]. Another example is electrochemical-based enzyme and hormone detection to inspect cancer, pregnancy, food toxicity, and pollution levels.…”

The Use of Aptamers and Molecularly Imprinted Polymers in Biosensors for Environmental Monitoring: A Tale of Two Receptors

“…However, these methods are complex, require multiple-steps, and are labor intensive with long assay-times (>1 day). The integration of MIPs and aptamers with biosensor devices as the bio-recognition elements for the detection of environmental pathogens (e.g., foodborne and waterborne) has been shown to be flourishing measures, due to their remarkable advances accredited to their excellent recognition specificity, ease of synthesis, low cost, and eco-friendly nature [94][95][96].…”