Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Abstract

Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

“…This technology appears in and is supported by their previously published work for dengue, yellow fever, and Ebola viruses (Yen et al, 2015). Our previous work discussed the Molecularly Imprinted Polymers (MIPs) and Surface Imprinted Polymers (SIPs)-based electrochemical biosensor for virus antigen detection (Cui et al, 2020). However, there are still few published articles for detection of the whole SARS-CoV-2 virus or their antigens.…”

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

“…This technology appears in and is supported by their previously published work for dengue, yellow fever, and Ebola viruses (Yen et al, 2015). Our previous work discussed the Molecularly Imprinted Polymers (MIPs) and Surface Imprinted Polymers (SIPs)-based electrochemical biosensor for virus antigen detection (Cui et al, 2020). However, there are still few published articles for detection of the whole SARS-CoV-2 virus or their antigens.…”

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

“…Chief among all of the MIP preparation methods (eg, spin‐coating, 39 composite making, 40 or drop‐coating 41 ), electrochemical polymerization has found great interest owing to their unique merits such as fast, and simple preparation procedure, making firm binds with the surface of the electrode, high reproducibility in various conducting materials, and easy control over the morphology and the thickness of the polymer film. Despite their excellent electrochemical behavior and great electropolymerization ability, there are few studies who has employed phenazines for molecular imprinting of proteins 8 .…”

A New Optical Fiber Probe-Based Quantum Dots Immunofluorescence Biosensors in the Detection of Staphylococcus aureus

“…Since the first oxygen biosensor appeared in 1962, biosensor operation has become simpler, smarter, faster and more accurate due to the advancement of biosensor-related technology. Therefore, there are increasing application studies in clinical and food aetiology detection (Rubab et al, 2018;Cui et al, 2020). In this study, we constructed a new set of quantum dots immunofluorescence biosensors that combined the advantages of biosensors with the high specificity of antigen-antibody immune interactions and the high sensitivity and stability of quantum dots fluorescence.…”

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

“…This technology appears in and is supported by their previously published work for dengue, yellow fever, and Ebola viruses (Yen et al, 2015). Our previous work discussed the Molecularly Imprinted Polymers (MIPs) and Surface Imprinted Polymers (SIPs)-based electrochemical biosensor for virus antigen detection (Cui et al, 2020). However, there are still few published articles for detection of the whole SARS-CoV-2 virus or their antigens.…”

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

“…Chief among all of the MIP preparation methods (eg, spin‐coating, 39 composite making, 40 or drop‐coating 41 ), electrochemical polymerization has found great interest owing to their unique merits such as fast, and simple preparation procedure, making firm binds with the surface of the electrode, high reproducibility in various conducting materials, and easy control over the morphology and the thickness of the polymer film. Despite their excellent electrochemical behavior and great electropolymerization ability, there are few studies who has employed phenazines for molecular imprinting of proteins 8 .…”

A New Optical Fiber Probe-Based Quantum Dots Immunofluorescence Biosensors in the Detection of Staphylococcus aureus

“…Since the first oxygen biosensor appeared in 1962, biosensor operation has become simpler, smarter, faster and more accurate due to the advancement of biosensor-related technology. Therefore, there are increasing application studies in clinical and food aetiology detection (Rubab et al, 2018;Cui et al, 2020). In this study, we constructed a new set of quantum dots immunofluorescence biosensors that combined the advantages of biosensors with the high specificity of antigen-antibody immune interactions and the high sensitivity and stability of quantum dots fluorescence.…”

Diagnostic methods and potential portable biosensors for coronavirus disease 2019

“…This technology appears in and is supported by their previously published work for dengue, yellow fever, and Ebola viruses (Yen et al, 2015). Our previous work discussed the Molecularly Imprinted Polymers (MIPs) and Surface Imprinted Polymers (SIPs)-based electrochemical biosensor for virus antigen detection (Cui et al, 2020). However, there are still few published articles for detection of the whole SARS-CoV-2 virus or their antigens.…”

Chemical binding of molecular‐imprinted polymer to biotinilated antibody: Utilization of molecular imprinting polymer as intelligent synthetic biomaterials toward recognition of carcinoma embryonic antigen in human plasma sample

“…Chief among all of the MIP preparation methods (eg, spin‐coating, 39 composite making, 40 or drop‐coating 41 ), electrochemical polymerization has found great interest owing to their unique merits such as fast, and simple preparation procedure, making firm binds with the surface of the electrode, high reproducibility in various conducting materials, and easy control over the morphology and the thickness of the polymer film. Despite their excellent electrochemical behavior and great electropolymerization ability, there are few studies who has employed phenazines for molecular imprinting of proteins 8 .…”

A New Optical Fiber Probe-Based Quantum Dots Immunofluorescence Biosensors in the Detection of Staphylococcus aureus

“…Since the first oxygen biosensor appeared in 1962, biosensor operation has become simpler, smarter, faster and more accurate due to the advancement of biosensor-related technology. Therefore, there are increasing application studies in clinical and food aetiology detection (Rubab et al, 2018;Cui et al, 2020). In this study, we constructed a new set of quantum dots immunofluorescence biosensors that combined the advantages of biosensors with the high specificity of antigen-antibody immune interactions and the high sensitivity and stability of quantum dots fluorescence.…”