State of metabolic processes and ways to improve them in premenopausal women due to the life extension strategy

Abstract

Increasing the duration and improving the quality of life of older women is a significant problem of current medicine. Metabolic disorders in the form of type II diabetes mellitus and atherogenic dyslipidemia lead to a significant level of cardiovascular complications. It is known that hormone replacement therapy cannot normalize age-related metabolic disorders. Therefore, the search for new methods of cardiovascular health is extremely relevant. Research objective: to study the state of autonomic nervous regulation, carbohydrate and lipid metabolism in perimenopausal women using the life extension approach.Materials and methods. Group I (control) consisted of 35 apparently healthy women of reproductive age. Group II (main) consisted of 71 patients whom was administered a solution of xylitol with electrolytes (Xylate) by infusion from the first days of the reduction diet for 5 days, and also L-arginine (Tivortin) was injected intravenously for 5 days, 200 ml once a day, followed by taking a drinking solution of this drug for another three weeks. All patients followed a 28-day diet, and also performed daily aerobic morning exercises for 3 months.Results. A significant decrease in body mass index in patients of the main group due to the proposed treatment and prevention program was found. At the same time, Kupperman index declined significantly. Decreased body mass index in patients of the main group was the basis for improved autonomic nervous regulation and metabolic processes. Xylate-Tivortin complex has allowed emphasizing the overcoming of insulin resistance, dyslipidemia and chronic inflammation.Conclusions. The developed 3-month program allowed to significantly improving the metabolic processes and hemodynamic parameters in women of perimenopausal age. This is the basis for the introduction of Xylate-Tivortin complex life extension into the practice of family physicians, obstetricians and gynecologists and specialists in the field of aesthetic medicine.

Ovarian Factors of Cardiovascular Disease: The Way to Go?

“…Administration of L-arginine should be started intravenously at 200 ml once a day for a week, and then be continued in oral form for another 3 weeks. The results of 1-month and 3-month programs, including physical training, diet, xylitol, and L-arginine, were already reported [53,54]. The findings showed a real prospect of such a strategy for life extension.…”

“…Weight gain and increased BMI was the main factor for insulin resistance, atherogenicity, and menopausal disorders. The use of diet, xylitol, and L-arginine improved metabolic processes and reduced menopausal disorders [53,54].…”

The pathogenic pathways of cardiovascular disease in perimenopausal women

“…Weight gain was the main factor for insulin resistance, atherogenicity, and menopausal disorders. The use of diet, xylitol, and L-arginine improved metabolic processes and reduced menopausal disorders [ 12 ].…”

“…The addition to HRT use of diet, L-arginine, and xylitol solutions could be a possible therapeutic strategy for life extension. This speculation was preliminarily tested in a 1-month program [ 12 ]. This research was designed to provide physicians with an efficient method to protect cardiovascular health and menopausal disorders in middle-aged women.…”