Star‐Shaped Poly(styrene)‐block‐Poly(4‐vinyl‐N‐methylpyridiniumiodide) for Semipermanent Antimicrobial Coatings

Abstract

Goal of the present work is to develop an antimicrobial coating that can be applied from an aqueous solution and resists short washing cycles, but can be rinsed off by thorough washing. To this end, a series of star-shaped polystyrene-block-poly(4-vinyl-N-methylpyridinium iodide) polymers are synthesized by anionic polymerization using a core-first approach. The optimal resulting polymers are applied as coatings on glass slides, showing high antimicrobial efficiency against Staphylococcus aureus as well as Escherichia coli. The coatings, characterized by atomic force microscopy and transmission electron microscopy, stay at the surface even after at least 20 flush-like washings with water, and retain their antimicrobial activity.

Nontoxic, Hydrophilic Cationic Polymers—Identified as Class of Antimicrobial Polymers

“…[16] Alternatively, hydrophilic macromolecules with high cationic charge density were found to be antimicrobially effective as well. [17,18] Another prerequisite for these polymers seems to be that they in contrast to amphiphilic polycations [19][20][21] should not be branched. [22][23][24] Ikeda et al who investigated the working mechanism of these polymers found that the macromolecules are always located in the surroundings of phosphate ions and concluded that the mode of action is based on membrane activity as predicted and found for many other polymers with cations in the side chain.…”

Telechelic Poly(2-oxazoline)s with a Biocidal and a Polymerizable Terminal as Collagenase Inhibiting Additive for Long-Term Active Antimicrobial Dental Materials

“…The molecular weights and the MIC values are given in Table 1 Determined (in triplicate) against the Gram-positive germ S. mutans; the maximum standard deviation was the next higher value; c) Dodecyltrimethylammonium chloride; d) Neither the initiator-(Me-), nor the hydroxyl-terminal (-OH) were sufficiently visible/integrable in NMR; DP calculation was performed on SEC-basis; e) This polymer is described in reference. [58] Poly(2-ethyloxazoline)s PEtOx. 1 13…”

Kontaktaktiv oder durch Biozide

“…[24][25][26][27] Als Beschichtungen aus wässrigen Suspensionen dienen antimikrobielle Stern-Blockcopolymere oder Polymernanopartikel, die mit antimikrobiellen Blockcopolymeren stabilisiert sind. 28,29) Eine weitere Variante ist die Be-schichtung durch Plasmapolymerisation von zum Beispiel Diallyldimethylammoniumchlorid. 30) All den genannten Methoden ist gemein, dass sie eine bereits bestehende Oberfläche nachträglich antibakteriell ausstatten.…”