Nontoxic, Hydrophilic Cationic Polymers—Identified as Class of Antimicrobial Polymers

Strassburg, Arne; Kracke, Frauke; Wenners, Julia; Jemeljanova, Anna; Kuepper, Jannis; Petersen, Hanne; Tiller, Joerg C.

doi:10.1002/mabi.201500207

Cited by 59 publications

(65 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…human erythrocyte) membranes generally contain higher proportion of zwitterionic lipids and possess cholesterol [32]. However, Strassburg et al have reported a class of non-hemocytotoxic hydrophilic polymers [35]. Although a variety of antibacterial polymers has been reported, the ability of polymers to disrupt surface established bacterial biofilms have been scarce.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

et al. 2016

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 98%

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

et al. 2016

View full text Add to dashboard Cite

“…For example, the preparation of cationic polymers with hydrophilic, non-hemolytic antimicrobial properties was achieved by controlling the alkyl backbone length of tetramethyldiamines and dibromoalkanes in a polyaddition reaction. 18 Poly(2-methyloxazoline) with a quaternary ammonium terminal and a cleavable ester satellite terminal was also reported to exhibit bactericidal activity with low hemotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Pranantyo

Zheng

et al. 2017

Polym. Chem.

View full text Add to dashboard Cite

A series of four-arm star copolymers, incorporating glycopolymer and antimicrobial polypeptide domains, was developed in the design of forthcoming anti-infective agents. Mannose, glucose, and galactosebased glycopolymers with a variety of well-defined chain lengths were prepared via atom transfer radical polymerization, whereas linear α-polylysine was prepared via ring-opening polymerization of N-carboxyanhydride monomers. Copper-catalyzed azide-alkyne cycloaddition was employed for 'click' conjugation of the glycopolymer arms and the polypeptide chains. The glycopolymer-polypeptide conjugates were non-hemolytic and exhibited higher cytocompatibility than the linear α-polylysine. The conjugates with shorter chains of mannose-based glycopolymer arms showed an enhanced bactericidal efficacy against Gram-negative and Gram-positive bacteria, with a therapeutic selectivity half of that of the linear α-polylysine. The pendant mannose moieties of the conjugates increased microbial targeting due to their specific affinity for bacterial surfaces, and binding competition with free mannopyranoside was demonstrated. Therefore, the molecular combination of glycopolymers and polypeptides without loss of their respective activities provides an interesting concept in the design of antimicrobial agents to combat infectious disease.

show abstract

“…In contrast, hydrophilic polycations often show a broader spectrum of activity. [9a] Moreover, they exhibit a by far less pronounced hemolytic activity against red blood cells than amphiphilic biocidal polymers and telechelic polymeric biocides. Both characteristics of hydrophilic polycations indicate a different mode of action, compared to telechelic biocidal polymers.…”

Section: Introductionmentioning

confidence: 99%

“…Both characteristics of hydrophilic polycations indicate a different mode of action, compared to telechelic biocidal polymers. [9a] Strassburg et al showed that the antimicrobial activity of hydrophilic polycations is additionally influenced by the end groups. [9a]…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action

Richter

Hijazi

Arfeen

et al. 2018

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Telechelic antimicrobial poly(2-oxazoline)s with quaternary ammonium (quat) end groups are shown to be potent antimicrobial polymers against Gram-positive bacterial strains. In this study, the activity against the Gram-negative bacterium Escherichia coli is additionally implemented by hydrolyzing the poly(2-methyl-2-oxazoline) with two quart end groups to poly(ethylene imine) (PEI). The resulting telechelic polycations are active against Staphylococcus aureus and E. coli. The contribution of the PEI backbone is determined by measuring the antimicrobial activity in the presence of calcium ions. The influence of PEI on the overall activity strongly depends on the molecular weight and increases with higher mass. The PEI dominates the activity against E. coli at lower masses than against S. aureus. The quart end groups require an alkyl substituent of dodecyl or longer to dominate the antimicrobial activity. Additionally, PEI and quart end groups act synergistically.

show abstract

Nontoxic, Hydrophilic Cationic Polymers—Identified as Class of Antimicrobial Polymers

Cited by 59 publications

References 46 publications

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Telechelic, Antimicrobial Hydrophilic Polycations with Two Modes of Action

Contact Info

Product

Resources

About