Kontaktaktiv oder durch Biozide

Krumm, Christian; Tiller, Joerg C.

doi:10.1002/nadc.201490359

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Contact-active surfaces exhibit antimicrobial activity without releasing biocidal substances. Several mechanisms are believed to take place in contact-active surfaces [31]. These are: (i) a so-called spacer effect, where the biocidal group is attached to the surface through a polymer chain, allowing the biocide to reach the cytoplasmic membrane of the bacteria and to perforate them; (ii) alternatively, positively charged QACs, e.g.…”

Section: Contact-active Surfacesmentioning

confidence: 99%

See 1 more Smart Citation

Surface modifications for antimicrobial effects in the healthcare setting: a critical overview

Adlhart

Verran

Azevedo

et al. 2018

Journal of Hospital Infection

251

218

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The spread of infections in healthcare environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (e.g. implants, catheters), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc., or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. This review addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated with the implementation of such anticontamination measures. Different chemistry-based approaches are discussed, for instance anti-adhesive surfaces (e.g. superhydrophobic, zwitterions), contact-killing surfaces (e.g. polymer brushes, phages), and biocide-releasing surfaces (e.g. triggered release, quorum sensing-based systems). The review also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (e.g. toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability) when developing and implementing antimicrobial surfaces.

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Section: Contact-active Surfacesmentioning

confidence: 99%

“…Biocide-releasing surfaces may have some conceptual disadvantages since they are toxic by design in terms of releasing biocidal substances. In addition they will gradually become inactive and they may induce the formation of resistance [31]. Catalytically active surfaces, such as photocatalytically active surfaces (e.g.…”

Section: Biocide-releasing Surfacesmentioning

confidence: 99%