Staphylococcus hominis Endophthalmitis Associated With a Capsular Hypopyon

Iyer, Mohan N.; Wirostko, William J.; Kim, Steve; Simons, Kenneth B.

doi:10.1016/j.ajo.2004.10.060

Cited by 12 publications

(9 citation statements)

References 4 publications

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“…It has been reported to cause some potentially life-threatening infections, such as infective endocarditis (6). A case of S. hominis endophthalmitis associated with a capsular hypopyon has also been reported (4). The increasing relevance of S. hominis to human health prompted us to determine the genomic sequence of S. hominis ZBW5, a multidrugresistant strain isolated from a normal human skin sample in our hospital.…”

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confidence: 99%

Whole-Genome Sequence of Staphylococcus hominis, an Opportunistic Pathogen

Jiang¹,

Zheng²,

Ding³

et al. 2012

Journal of Bacteriology

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Staphylococcus hominis is a commensal coagulase-negative species of staphylococci. It has been considered a presumptive and opportunistic pathogen that causes nosocomial infections in humans. Here we present the draft genome sequence of S. hominis ZBW5, a multidrug-resistant strain isolated from a human skin sample, which provides opportunities to understand the mechanism and genetic basis of its pathogenesis.

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confidence: 99%

Whole-Genome Sequence of Staphylococcus hominis, an Opportunistic Pathogen

Jiang¹,

Zheng²,

Ding³

et al. 2012

Journal of Bacteriology

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“…Previously, Iyer et al reported that patients with S. hominis endophthalmitis have a subacute onset and are asymptomatic 5. However, the present case had an acute-onset postoperative endophthalmitis.…”

Section: Discussionmentioning

confidence: 46%

Vancomycin-resistant Staphylococcus hominis endophthalmitis following cataract surgery

Won

Kim²

2013

OPTH

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We report a case of acute postoperative endophthalmitis caused by vancomycin-resistant Staphylococcus hominis, treated at our hospital. An 80-year-old male presented 2 days after uncomplicated phacoemulsification and posterior chamber intraocular lens implantation, with a 24-hour history of progressive visual loss and redness in the operated (right) eye. On examination, best corrected visual acuity was counting fingers. Anterior segment examination revealed conjunctival injection, chemosis, corneal edema, and hypopyon. B-scan ultrasonography showed vitreous opacification, but no retinal detachment. Acute postoperative endophthalmitis was diagnosed. We performed vitrectomy with vancomycin in the irrigating solution, intraocular lens removal, and silicone oil tamponade. Culture of the vitreous grew Staphylococcus hominis. Antibiotic susceptibility testing showed the isolate was sensitive to trimethoprim/sulfamethoxazole and teicoplanin but resistant to ciprofloxacin, moxifloxacin, levofloxacin, cefazolin, and vancomycin. At 3 months, the visual acuity of the silicone oil-treated eye was 20/400.

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“…Corynebacterium has been previously described to be associated with endophthalmitis after YAG capsulotomy and has been demonstrated to stay sequestered within the capsular bag and even form a capsular hypopyon. 31, 32, 35 None of the patients in the current series required intraocular lens removal or capsulectomy, which is commonly required when treating endophthalmitis caused by Propionbacterium acnes , the most common cause of delayed-onset endophthalmitis. 46 Although persistently positive vitreous cultures in endophthalmitis caused by Corynebacterium species have been reported, there were no cases of persistently positive vitreous cultures in the current series.…”

Section: Discussionmentioning

confidence: 92%

Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes

Kuriyan

Sridhar

Flynn

et al. 2017

Ophthalmology Retina

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Purpose To report the clinical features, antibiotic susceptibility profiles, treatment, and visual acuity (VA) outcomes of endophthalmitis caused by Corynebacterium species. Design Retrospective case series. Subjects Patients with endophthalmitis caused by Corynebacterium species. Methods Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Corynebacterium species from January 1, 1990 to December 31, 2012 at a large university referral center. The corresponding clinical records were then reviewed to evaluate the endophthalmitis clinical features and treatment outcomes. Main Outcome Measures presenting clinical features, visual acuity outcomes, and antibiotic susceptibility patterns. Results Of 10 patients identified, clinical settings included post-cataract surgery (n = 6), post-penetrating keratoplasty (n = 2), and post-trabeculectomy (n = 2). The mean time from surgical procedure to presentation with endophthalmitis was 6.8 months (range: 1 day to 28 months). All isolates were vancomycin susceptible. Presenting VA ranged from 7/200 to no light perception. Initial treatment strategies were vitreous tap and intravitreal antibiotic injection (n = 5) and pars plana vitrectomy with intravitreal antibiotic injection (n = 5). VA outcomes were ≥ 20/60 in 5 (50%) of 10 patients and ≤ 20/400 in 5 (50%) of 10 patients. Conclusions The most common clinical setting was post-cataract surgery. All isolates were susceptible to vancomycin. Despite prompt treatment with appropriate antibiotics, there were variable visual outcomes.

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Staphylococcus hominis Endophthalmitis Associated With a Capsular Hypopyon

Cited by 12 publications

References 4 publications

Whole-Genome Sequence of Staphylococcus hominis, an Opportunistic Pathogen

Whole-Genome Sequence of Staphylococcus hominis, an Opportunistic Pathogen

Vancomycin-resistant Staphylococcus hominis endophthalmitis following cataract surgery

Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes

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