Staphylococcus aureus in psoriasis

Marples, R. R.

doi:10.1001/archderm.107.4.568

Cited by 35 publications

(26 citation statements)

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“…2,3 In psoriasis (PS), S aureus was detected in nonlesional skin of 27% of patients and in 46% of lesions. 4 S aureus has also been isolated from skin of patients with erythroderma. 5 In a study of 42 patients, 76% were positive for S aureus in culture from blood or skin.…”

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confidence: 99%

Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects

Tomi¹,

Kränke²,

Aberer³

2005

Journal of the American Academy of Dermatology

143

122

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mentioning

confidence: 99%

Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects

Tomi¹,

Kränke²,

Aberer³

2005

Journal of the American Academy of Dermatology

143

122

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“…In a previous study of 42 psoriasis patients, S. aureus colonized 46% of the lesional skin and 27% of nonlesional skin [11]. Because the frequency of isolates in the present study was lower, an additional sampling method used by Marples et al [11], the detergent scrub technique, was also tried.…”

Section: Discussionmentioning

confidence: 88%

“…Because the frequency of isolates in the present study was lower, an additional sampling method used by Marples et al [11], the detergent scrub technique, was also tried. However, the number of strains isolated from skin with this technique (data not shown) was not significantly different from the results shown in table 2.…”

Section: Discussionmentioning

confidence: 99%

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Superantigen Production by <i>Staphylococcus aureus </i>in Psoriasis

et al. 1998

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Background: Activation of T cells is believed to play a critical role in the pathogenesis of psoriasis. Recently, it has been proposed that psoriasis is a T-cell-mediated autoimmune reaction triggered by bacterial superantigen. Objective: We investigated whether patients with chronic plaque psoriasis bear superantigen-producing Staphylococcus aureus on the skin or the throat. Methods: S. aureus producing exfoliative toxin, staphylococcal enterotoxin B or toxic shock syndrome toxin 1 was isolated from the skin and throat of 100 psoriasis patients using Western blot analysis and polymerase chain reaction. Results: Only 5, 4 and 9 patients had super-antigen producing S. aureus identified on lesional skin, nonlesional skin and throat, respectively. The vast majority of patients did not bear superantigen-producing S. aureus. Conclusion: We believe that superantigens are not essential in sustaining disease activity but may, instead, be exacerbating or triggering factors for some psoriasis patients.

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“…A number of clinical reports suggest that bacterial infection can trigger psoriasis, and it has been known for a long time that acute exacerbation of psoriasis may follow streptococcal infection [18,19,20,21]. The resulting psoriasis is commonly of the guttate pattern, but existing plaque psoriasis may also be exacerbated [3, 21].…”

Section: Discussionmentioning

confidence: 99%

Medical History, Drug Exposure and the Risk of Psoriasis

et al. 2008

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Background/Aims: To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Methods: Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. Results: The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5–1.3) in hypertensive subjects, 1.1 (95% CI 0.6–2.0) in diabetics and 1.1 (95% CI 0.7–1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1–0.8). Conclusion: Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.

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Staphylococcus aureus in psoriasis

Cited by 35 publications

References 0 publications

Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects

Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects

Superantigen Production by <i>Staphylococcus aureus </i>in Psoriasis

Medical History, Drug Exposure and the Risk of Psoriasis

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