Medical History, Drug Exposure and the Risk of Psoriasis

Abstract

Background/Aims: To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Methods: Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. Results: The odds ratio (OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5–1.3) in hypertensive subjects, 1.1 (95% CI 0.6–2.0) in diabetics and 1.1 (95% CI 0.7–1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1–0.8). Conclusion: Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself.

Adiponectin resides in mouse skin and upregulates hyaluronan synthesis in dermal fibroblasts

“…Dysregulation of adipokines in obesity is thought to play a role in the development of obesity-linked disorders such as insulin resistance, cardiovascular disease, and hypertension. In addition, skin disorders such as psoriasis and woundhealing aberration also have known associations with obesity and diabetes [2][3][4][5][6]. On this basis, we believe that adipose tissue is likely to affect skin function.…”

MCP-1 in psoriatic patients: effect of biological therapy

“…Psoriasis is a chronic inflammatory skin disease, whose prevalence in the Italian population has been estimated to be 2.8% (1). Immune-mediated mechanisms involving T helper (Th)-1 and Th-17 lymphocytes, multiple cytokines and chemokines are responsible for disease manifestations.…”

Psoriasis and Risk of Type 2 Diabetes among Women and Men in the United States: A Population-Based Cohort Study

“…The prevalence of co-morbidities such as insulin resistance, metabolic syndrome and type 2 diabetes (T2D) associated with psoriasis has gained interest in recent years, while most were cross-sectional (Cohen et al, 2008; Driessen et al, 2009; Henseler and Christophers, 1995; Kimball et al, 2008; Lindegard, 1986; Love et al, 2011; Neimann et al, 2006; Pearce et al, 2005) or case-control studies (Brauchli et al, 2008; Gerdes et al, 2008; Gisondi et al, 2007; Naldi et al, 2008; Shapiro et al, 2007; Sommer et al, 2006; Vena et al, 2010; Wu et al, 2008), and inflammation seems to be an underlying mechanism (Davidovici et al, 2010; Hu et al, 2004; Pradhan et al, 2001). …”