Adiponectin resides in mouse skin and upregulates hyaluronan synthesis in dermal fibroblasts

Abstract

Adipose tissue is a hormonally active tissue that produces adipokines that influence the activity of other tissues. Adiponectin is an adipocyte-specific adipokine involved in systemic metabolism. We detected the expression of adiponectin receptors (AdipoR1 and AdipoR2) mRNA in cultured dermal fibroblasts. The full-length adiponectin (fAd), but not the globular adiponectin (gAd), increased hyaluronan (HA) production and upregulated HA synthase (HAS) 2 mRNA expression. AdipoR1 and AdipoR2 mRNAs were also expressed in keratinocytes, though neither fAd nor gAd had any effect on HA synthesis. In mouse skin, we found that adiponectin was present and decreased markedly with aging. The age-dependent pattern of adiponectin decrease in skin, correlated well with that of HA in skin. Our experiments were also the first to identify adiponectin production in cultured mouse sebocytes, a finding that suggests that skin adiponectin may derive not only from plasma and/or subcutaneous adipose tissue, but also from the sebaceous gland. These results indicated that adiponectin plays an important role in the HA metabolism of skin.

Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

“…In addition, adiponectin is a hair growth stimulator that increases the secretion of growth factors from dermal papillae cells and hair matrix keratinocyte proliferation [5]. Moreover, adiponectin induces proliferation of dermal fibroblasts and upregulation of collagen production [6] and promotes hyaluronan synthesis with increased hyaluronan synthase [7, 8]. The age-dependent decreasing pattern of adiponectin in skin suggests the possibility that adiponectin plays a role in skin aging [8].…”

Adipocytes in Skin Health and Disease

“…Supporting this theory, adiponectin can regulate the expression of several cytokines that activate the immune system (Takahashi et al 2010) and can modulate keratinocyte proliferation and migration through the ERK signaling pathway (Shibata et al 2012). Moreover, adiponectin receptors are expressed in cultured dermal cells (Akazawa et al 2011) and adiponectin can promote hair growth in vitro (Won et al 2012), hinting at the possibility that adiponectin derived from dermal adipocytes might also regulate hair follicle biology.…”

Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes

“…A study has recently reported the presence of adiponectin in mouse skin . Although it is possible that adiponectin may move from the bloodstream to the skin, sebocytes in the sebaceous gland can produce adiponectin .…”