Psoriasis and Risk of Type 2 Diabetes among Women and Men in the United States: A Population-Based Cohort Study

Abstract

Type 2 diabetes (T2D) shares some common risk factors with psoriasis. We evaluated the association between psoriasis and risk of incident T2D among women and men in the United States in a mixed retrospective-prospective cohort study. 184,395 participants were included from an older cohort of women (the Nurses’ Health Study, NHS) (1996–2008), a younger cohort of women (NHS II) (1991–2007) and an older cohort of men (Health Professionals’ Follow-Up Study, HPFS) (1986–2006). During 2,700,958 person-years of follow-up, 9,938 incident T2D cases were confirmed. We found a significantly increased risk of T2D associated with psoriasis only among younger women (NHS II); multivariate-adjusted relative risk (RR) (95% confidence interval (CI)) was 1.25 1.05–1.49). When only including those younger than 60 years during follow-up (NHS and HPFS), we observed a non-significant trend toward increased risk for T2D. In a pooled-analysis of the three cohorts, psoriatics younger than 60 years were at a higher risk of T2D; RR 1.26 (1.08–1.48) for women, and 1.26 (1.08–1.46) for both sexes combined. Further, the risk of T2D was much higher for those developing psoriasis at an early age. In conclusion, we found an association between psoriasis and risk of T2D among individuals younger than 60 years.

Hypercholesterolemia and Risk of Incident Psoriasis and Psoriatic Arthritis in US Women

“…In particular, psoriasis self-reports have reached a confirmation rate of 92% (22). Furthermore, we compared the characteristics of participants who responded to psoriasis questions with those who did not respond, and found that the main characteristics (e.g., BMI, smoking, and alcohol intake) were similar between responders and non-responders (42). Therefore, it is less likely that our results would differ greatly due to response bias.…”

Impact of metabolic status on the incidence of psoriasis: A Korean nationwide cohort study

“…Some data are available regarding the association between psoriasis and individual disease onset risk. Certain studies have reported that psoriasis is associated with a high risk of DM development [18][19][20] , but only few studies have assessed the association of psoriasis with HTN development 21,22 . Nevertheless, most of the studies were cross-sectional in nature and hence lacked a temporal order.…”

Psoriatic patients with diabetes are prone to develop digestive organ cancers: A population-based study in Taiwan

“…These results indicated that there is a link between development of psoriasis and diabetes. In fact, recent report has found an association between psoriasis and risk of diabetes in a population-based cohort study [14]. Different studies have suggested that psoriatic patients carry an elevated risk of malignancy although conflicting results have been reported [15][16][17].…”