Staphylococcal pyoderma: challenges and therapeutic considerations

Bajwa, Jangi

doi:10.1136/vr.k1563

Cited by 12 publications

(16 citation statements)

References 16 publications

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“…Bacteria are found on skin surface, in the superficial part called stratum corneum but they are absent in the external area of the hair follicle and up to the sebaceous gland. Several bacterial species can coexist in harmony without causing any damage to the skin; however instability can occur at any point [4][5][6][7]. The skin microbiota consists of resident bacteria and occasionally transient bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Susceptibility Profile of Pseudomonas Aeruginosa Canine Isolates from a Multicentric Study in Romania

Dégi¹,

Moțco²,

Dégi³

et al. 2021

Preprint

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Treating infections caused by Pseudomonas aeruginosa is increasingly difficult due to high antimicrobial resistance, materialized through the presence of multiple resistance strains, as well as due to rapid development of resistance throughout treatment. The present survey was conducted to investigate the antibiotic susceptibility profile of Pseudomonas aeruginosa pathogens, in two University Veterinary hospitals from different geographical regions of Romania (i.e., south-west - Timisoara county and north-east – Iasi county) involved in canine superficial infections. A total of 142 swab specimens were collected from dogs with superficial infections (superficial skin infections, otitis externa, perianal abscess), with the aim of assessing the presence of Pseudomonas aeruginosa, based on phenotypic and molecular characterization. Fifty-eight samples (40.84%; 58/142) were positive for Pseudomonas aeruginosa (according to their confirmed morphological and molecular features). Susceptibility to usual antibiotics used in the treatment of canine skin conditions was tested for all Pseudomonas strains that were isolated from canine superficial infections, using the Kirby Bauer disc diffusion method. Drug resistance was observed in the case of all tested antibiotics. The susceptibility rate of P. aeruginosa strains that were tested in this study was in the following order: ampicillin sulbactam (55.17%; 32/58), followed by ceftazidime (53.44%; 31/58), aztreonam (51.72%; 30/58), amikacin (44.82%; 26/58), azithromycin (41.37%; 24/58), gentamycin (37.93%; 22/58), cefepime (36.20%; 21/58) meropenem (25.86%; 13/58), piperacillin-tazobactam (25.86%; 13/58) imipenem (22.41%; 13/158), ciprofloxacin (17.24%; 10/58) tobramycin (8.62; 5/58), and polymyxin B (1.72; 1/58) respectively. The results highlight the importance of antibiotic susceptibility testing in Pseudomonas aeruginosa isolates from dogs with superficial infections, in order to use an adequate treatment plan for the management of the skin condition, and other pathology (otitis externa and perianal abscesses).

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Section: Introductionmentioning

confidence: 99%

Antibiotic Susceptibility Profile of Pseudomonas Aeruginosa Canine Isolates from a Multicentric Study in Romania

Dégi¹,

Moțco²,

Dégi³

et al. 2021

Preprint

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“…Moreover, it can also infect ears and skin of other animals such as cats, parrots and horses [4]. Systemic and topical antibiotics are currently used to treat superficial and deep canine staphylococcal pyoderma, but longterm treatments are required and most animals suf-fer from recurrent infections [5]. Today, the development of antibiotic resistance in the causative bacteria is an important problem in veterinary medicine and public health, especially methicillin-resistant S. pseudintermedius [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-biofilm activity of Thai herbal essential oils against Staphylococcus pseudintermedius causing canine pyoderma

Aiemsaard¹,

Kamollert²,

Singh³

et al. 2020

ScienceAsia

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The aim of this study was to investigate the efficacy of 11 essential oils (EOs) against Staphylococcus pseudintermedius planktonic and biofilm forms. Twenty three bacterial samples were collected from dogs with superficial pyoderma and 9 samples were identified as S. pseudintermedius by polymerase chain reaction-restriction fragment length polymorphism method. The minimum planktonic inhibitory concentration (MPIC), minimum planktonic bactericidal concentration (MPBC) and minimum biofilm eradication concentration (MBEC) of EOs were determined by broth microdilution using a transferable solid phase. Among all, lemongrass EO was the most effective against both planktonic and biofilm forms of S. pseudintermedius with the MPIC, MPBC and MBEC of 0.02, 0.039 and 0.078% v/v, respectively. EOs of betel vine and citronella had the second most inhibitory effect (MPIC and MPBC: 0.039% v/v and MPBC: 0.156% v/v) followed by clove (MPIC and MPBC: 0.078% v/v) and sweet basil (MPIC and MPBC: 0.625% v/v). The EOs of ginger, plai, kaffir lime, turmeric, holy basil and galanga had the lowest inhibitory effect with MPICs and MPBCs ranging from 1.25% v/v to greater than 2.5% v/v. The results of this study indicated that the anti-planktonic and anti-biofilm effects of the tested EOs were concentration dependent, and higher concentrations were required for anti-biofilm activity. Lemongrass EO showed the most potential as a therapeutic antimicrobial agent for both planktonic and biofilm forms of S. pseudintermedius.

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“…Superficial pyoderma is a bacterial infection confined to the superficial portion of the skin. Bacteria may cause an infection secondary to local trauma, scratching, contamination due to poor grooming, seborrhea, parasitic infestation, hormonal factors, local irritants and allergies in dogs (Bajwa, 2016). Lesions may be quite superficial and may affect only the epidermis or may involve deeper structures in the dermis or subcutaneous tissue.…”

Section: Introductionmentioning

confidence: 99%