Standardizing Nanomaterials

Mulvaney, Paul; Parak, Wolfgang J.; Caruso, Frank; Weiss, Paul S.

doi:10.1021/acsnano.6b07629

Cited by 46 publications

(40 citation statements)

References 3 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was also restricted to a target population and conclusions can hardly be extrapolated. In the literature, the investigation of nanoparticles in patients' samples is rare and when it exists it is limited to electron microscopy observations that do not allow a complete physicochemical characterization of the 13014:2012Mulvaney et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

et al. 2017

View full text Add to dashboard Cite

Mineralogical analyses of clinical samples have been proved useful to identify causal relationship between exposure to airborne particles and pulmonary diseases. The most striking example is asbestosis where the assessment of asbestos bodies in patient lung samples has allowed defining values specific of pathologies. However this type of analyses only considers the micro-sized fraction of the particles, neglecting the specific impact of nano-sized particles which have been otherwise shown to be reactive and able to induce biological effects.Similarly, in nanotoxicology, the mineralogical analysis of pulmonary fluids could be used as an indicator of exposure to inhaled nanoparticles and could help investigations on the relationship between exposure to these nanoparticles and lung diseases. We designed this study first to demonstrate the technical feasibility of this approach, then to get a clear picture of the metals present, and in what form, in patient lungs and finally to determine if indeed it is worth investigating separately the micro, sub-micro and nano fractions. Broncho-alveolar lavages were recovered from 100 patients suffering from interstitial lung diseases. A protocol was specifically developed to isolate 3 fractions containing respectively microparticles, submicroparticles and nanoparticles with ions. The metal content in each fraction was qualitatively and quantitatively characterized. Results showed significant differences between the 3 fractions in terms of metal load confirming that the separate analysis of the fractions is relevant. It also means that the assessment of the micro-sized fraction alone, as commonly done in clinical practice, only gives a partial view of the mineralogical analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Other techniques that are starting to become part of the characterization scheme of NPs prior to use in humans are dynamic light scattering, transmission electron microscopy, gel electrophoresis, and ζ-potential analysis. However, there are no standardized characterization requirements of NPs 26 prior to use in humans, and this must be a focus for nanomedicine applications. The main reason is that the biodistribution and interaction of NPs with proteins is strongly size- and surface-dependent, and thus, in a heterogeneous sample, many NPs will distribute differently and may exhibit undesired effects or even toxicity.…”

mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

Self Cite

View full text Add to dashboard Cite

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

show abstract

“…The chemical reactivity depends on the types and geometry of the surface facets, but it is difficult to provide statistically reliable information on the surface facet structure of a large number of rods today. Transmission electron microscopy (TEM) studies are inherently limited to individual rods; conventional X‐ray scattering does not allow us to distinguish surface facets from the bulk ones, and atomic force microscopy (AFM) usually cannot provide atomic resolution on nanoparticles …”

mentioning

confidence: 98%

Determination of the Surface Facets of Gold Nanorods in Wet‐Coated Thin Films with Grazing‐Incidence Wide Angle X‐Ray Scattering

Zhang

Rothkirch

Koch

et al. 2019

Part & Part Syst Charact

View full text Add to dashboard Cite

This work studies the surface facets of gold nanorods (AuNRs) in wet‐coated nanoparticle thin films with synchrotron‐light‐based grazing‐incidence wide angle X‐ray scattering (GIWAXS), which provides statistically relevant results on many nanoparticles. Air‐brush spraying deposits the monodisperse AuNRs into sparse monolayers where the long axis of rods is parallel to the substrate surface. It is found that the crystalline facets of individual AuNRs in the sparse monolayer are all in the same orientation, as indicated by narrow azimuthal widths of (200) reflections, over a macroscopic scale comparable to the substrate. This alignment is probably due to the rods' sitting on high‐index surface facets such as (520) and (250). A quantitative analysis of the angles between bulk facets and the surface facets leads to a “nested‐octagon” model for the cross sections of AuNRs: shell octagon with high‐index crystalline facets (520), (5‐20), (2‐50), (‐2‐50), (‐5‐20), (‐520), (‐250), and (250), and core octagon consisting of low‐index crystalline facets (100), (1‐10), (0‐10), (‐1‐10), (‐100), (‐110), (010), and (110).

show abstract

Standardizing Nanomaterials

Cited by 46 publications

References 3 publications

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

Metal load assessment in patient pulmonary lavages: towards a comprehensive mineralogical analysis including the nano-sized fraction

Diverse Applications of Nanomedicine

Determination of the Surface Facets of Gold Nanorods in Wet‐Coated Thin Films with Grazing‐Incidence Wide Angle X‐Ray Scattering

Contact Info

Product

Resources

About