Standardized extract of Piper ovatum (Piperaceae) to control Aedes aegypti larvae (Diptera: Culicidae)

Κanis, Luiz Alberto; Rabelo, Bruna Daniel; Moterle, Diego; Nogaretti, Ricardo Machado; Nunes, Thiago; Silva, Onilda Santos da; Prophiro, Josiane Somariva

doi:10.1016/j.indcrop.2013.08.034

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…The PnE residual larvicidal activity observed was similar to that found in other studies with Piperaceae extracts in which maximal activity was maintained for a maximum of 15 days and was concentration dependent (12) (42) . After this period, activity decreased, which was attributed to degradation of the active ingredients (19) .…”

Section: Discussionsupporting

confidence: 88%

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Custódio

Oliveira

Moterle

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The signifi cant increase in dengue, Zika, and chikungunya and the resistance of the Aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. The aim of this study was to develop a controlled-release device containing Piper nigrum extract and to study its larvicidal activity against Aedes aegypti. Methods: Piper nigrum extract was produced by maceration, standardized in piperine, and incorporated into cotton threads, which were inserted into hydrogel cylinders manufactured by the extrusion of carrageenan and carob. The piperine content of the extract and thread reservoirs was quantifi ed by chromatography. The release profi le from the device was assessed in aqueous medium and the larvicidal and residual activities of the standardized extract as well as of the controlled-release device were examined in Aedes aegypti larvae. Results: The standardized extract contained 580mg/g of piperine and an LC 50 value of 5.35ppm (24h) and the 3 cm thread reservoirs contained 13.83 ± 1.81mg of piperine. The device showed zero-order release of piperine for 16 days. The P. nigrum extract (25ppm) showed maximum residual larvicidal activity for 10 days, decreasing progressively thereafter. The device had a residual larvicidal activity for up to 37 days. Conclusions: The device provided controlled release of Piper nigrum extract with residual activity for 37 days. The device is easy to manufacture and may represent an effective alternative for the control of Aedes aegypti larvae in small water containers.

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Section: Discussionsupporting

confidence: 88%

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Custódio

Oliveira

Moterle

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…aegypti oviposition behavior is of importance when it comes to evaluating the potential of S. rubra extract as a larvicide used in stagnant water. A repulsive effect regarding oviposition would indeed lead the mosquitoes to lay eggs in other, untreated sites, and therefore at once make such treatment irrelevant and favor the dispersion of the vector (Kanis et al 2013). Concurrently, we observed that larval hatching response measured for the CAY strain eggs did not vary significantly depending on the breeding site medium type.…”

Section: Discussionmentioning

confidence: 61%

“…Plants and plant-derived substances are often known to possibly interfere with oviposition effect, leading to either repellent or attractant effect, notably at concentrations greater than 50 µg/ml (Kanis et al 2013;El Maghrbi and Hosni 2014;Satho et al 2015;Seenivasagan et al 2019). In our case, the absence of repulsive effect concerning Ae.…”

Section: Discussionmentioning

confidence: 99%

“…The strong and rapid acute toxicity can represent a technical advantage in the field. (Darriet et al 2010) The lasting residual activity suggests an effective potential of the formulation for vector population inhibition during dengue transmission periods, which is a key parameter for disease control (Kanis et al 2013(Kanis et al , 2018Maia et al 2019). Botanical products often have to face the problem of residual activity, due to a high biodegradability through photodegradation, abiotic oxidation or volatilization (Amer and Mehlhorn 2006;Isman 2020).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and selectivity of Sextonia rubra wood extracts and formulation in the control of Aedes aegypti strains

Clervil,

Duchemin,

Amusant

et al. 2024

J Pest Sci

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Sextonia rubra is an Amazonian tree known for the larvicide activity of its wood extracts against Aedes aegypti. However, the lipophilic character of this extract represents an obstacle to the development of vector management products. The purpose of this study was to assess the feasibility, efficacy and selectivity of a water-soluble formulation based on a S. rubra wood extract characterized by its content in the larvicidal compounds rubrenolide and rubrynolide. Using reference and wild strains, the larval mortality, oviposition behavior, hatching response, and fitness of the mosquitoes exposed to the extract were evaluated. Laboratory eco-and cytotoxicity bioassays were concurrently performed. The extract showed larvicide efficacy alongside with no repulsive effect on oviposition, thus supporting its interest for the treatment of breeding sites. The formulation exhibited strong acute toxicity, leading to 100% larval mortality in 2 to 4 days either in dry or rainy season at the test dose of 102 µg/ml under semioperational conditions, with a residual activity maintained during the 5 weeks of test.The formulation allowed for a noticeable gain in selectivity compared with the extract, with lower immobilization rates for D. magna and C. riparius, and no significant toxicity towards human cells lines (IC 50 > 100 µg/ml). These results highlight the potential of a S. rubra-based formulation for the management of Ae. aegypti larvae, including strains showing resistance to conventional insecticides.

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Change in susceptibility response of Aedes aegypti (Diptera: Culicidae) to organophosphate insecticide and Copaifera oleoresin

et al. 2021

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Standardized extract of Piper ovatum (Piperaceae) to control Aedes aegypti larvae (Diptera: Culicidae)

Cited by 8 publications

References 34 publications

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Efficacy and selectivity of Sextonia rubra wood extracts and formulation in the control of Aedes aegypti strains

Change in susceptibility response of Aedes aegypti (Diptera: Culicidae) to organophosphate insecticide and Copaifera oleoresin

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