Standardization of Phyllanthus niruri and Sonchus arvensis as Components of Scientific Jamu

Jayani, Nikmatul Ikhrom Eka; Krisnawan, Alfian Hendra; Oktaviyanti, Nina Dewi; Kartini, Kartini

doi:10.22146/mot.45955

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…A lower water content results in the growth of less mold, fungus, and enzymatic reactions that can degrade the product's quality. 23 The bulbs contain 0.53% total ash, 0.28% acid-insoluble ash, and 0.29% water-soluble ash, as shown in Table 4. The higher the total ash content obtained, the higher the mineral content contained in the simplicia.…”

Section: Pharmacognostic Studymentioning

confidence: 99%

Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria

2022

TJNPR

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The experimental results showed that the cream Bawang Dayak does not cause significant irritation in the test animals or humans. [10][11][12][13] Therefore, this study aims to identify the pharmacognostic investigation of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.). It also aims to make a new product, specifically a clay mask with the same purpose as the previous studies, which is expected to produce a series of anti-acne treatments from the main materials Bawang Dayak. Materials and Methods Plant Collection and IdentificationBawang dayak (Figure 1) were collected at Jalan Cendrawasih II UPT.

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Section: Pharmacognostic Studymentioning

confidence: 99%

Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria

2022

TJNPR

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“…Various studies showed that P. niruri contains flavonoids, alkaloids, tannins, polyphenols, saponins, terpenoids, and lignans [7,8]. Some studies have also shown differences in the phytochemical content from different growing conditions, processing methods, and harvest times [2,9]. While several studies have substantiated the advantageous properties of P. niruri extract, the outcomes obtained exhibit notable variability.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds and In Vitro Evaluation of Phyllanthus niruri Extract as Antioxidant and Antimicrobial Activities

Hasan,

Safarianti,

Ramadhani

et al. 2024

Trends Sci

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Phyllanthus niruri grows easily in Indonesia and is widely used in traditional medicine. Differences in growing conditions, methods of preparation, and harvest time greatly affect the phytochemical contents, affecting the efficacy and toxicity of medicinal plants. This study aims to identify the phytochemical contents and toxicity and determine the antioxidant and antimicrobial activities of Phyllanthus niruri extract (PNE) commonly used by people in Aceh. Phytochemical analysis was carried out qualitatively and semi-quantitatively with GC-MS. A toxicity test was carried out with the brine shrimp lethality test (BSLT). The antioxidant activity was assessed by measuring IC50 against the DPPH system. Antimicrobial assays against Staphylococcus aureus, Escherichia coli, and Candida albicans were determined based on the disc diffusion test. The results of this study indicate that PNE contains phenolics, flavonoids, tannins, steroids, saponins, and alkaloids. Based on the semiquantitative phytochemical analysis using GC-MS, the major phytochemical component of PNE is 2,3 dihydro-3-5-dihydroxy-6-methyl-4H-pyran-4-one, hexadecanoic acid, triazole derivates, linolenic acid, benzaldehyde 3,4-dimethoxy, hexahydroanthracene derivatives, and phytol. The LC50 PNE is 532.96 ppm. The IC50 value for PNE in inhibiting DPPH is 56.72 ppm. PNE has antimicrobial activity against S. aureus, directly proportional to the increase in concentration. PNE obtained in community yards in Aceh has a low level of toxicity with potent antioxidant and antimicrobial activity against S. aureus. HIGHLIGHTS Phyllanthus niruri (PNE) extract contains various compounds such as phenolics, flavonoids, alkaloids, steroids, tannins, and saponins PNE exhibits strong antioxidant activity with low toxicity Antimicrobial activity of PNE against the growth of S. aureus while exhibiting comparatively lower potency against E. coli and C. albicans GRAPHICAL ABSTRACT

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“…The development and advancement of technology are currently attracting the attention of several researchers, especially in the field of natural product development, to develop several plants as medicine to support public health 1 . The community has long used natural materials as an empirical medicine to treat several diseases 2 . Indonesian traditional medicinal plants are increasingly used as standardized traditional medicines and phytopharmacology.…”

Section: Introductionmentioning

confidence: 99%

Standardization and Gc-MS Analysis of Kersen (Muntingia Calabura L.) Fruit Ethanol Extract as an Herbal Raw Material

Nur¹,

Aisyah²,

Nursamsiar³

et al. 2023

Bulletin of Pharmaceutical Sciences. Assiut

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Kersen (Muntingia calabura) is a plant widely reported to have pharmacological effects so it can be developed as a traditional medicine. This study aims to standardize the ethanol extract of kersen fruit from various locations where it grows in South Sulawesi Province, Indonesia. Standardization-specific parameters were carried out, including organoleptic analysis, phytochemical profiles, water, insoluble ethanol extracts, phenolic content, and total flavonoids. Non-specific parameters include total ash content, acid insoluble ash content, water content, drying shrinkage, specific gravity, and heavy metal contamination content of Pb, Cd, and Cu. The ethanol extract of the kersen fruit was also followed by GC-MS analysis. Specific parameters in the chemical content analysis showed the presence of groups of phenolic compounds, tannins, saponins, alkaloids, steroids, and terpenoids. The water-soluble extract content yielded <2%, and the ethanol-soluble extract content was 14-15.12%; The total phenolic content obtained was 11-12.20% EAG; total flavonoids obtained levels of 3-6.34% EQ. Non-specific parameters indicate that the total ash content is 0.19-0.31%; acid-insoluble ash content of 1.09-1.33%; water content <10%; Drying shrinkage <4%; specific gravity of 1.01-1.07 g/mL; total plate number and mold and yeast numbers obtained the number of colonies <20 colonies/g; and the content of Pb, Cd, and Cu respectively obtained levels of 0 mg/Kg. The results of the GC-MS analysis obtained 36 compounds belonging to the benzoate, phenolic, alkaloid, terpenoid, steroid, and fatty acid ester groups. It can be concluded that the ethanol extract of kersen fruit can be considered a raw material for developing traditional medicine in Indonesia.

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Standardization of Phyllanthus niruri and Sonchus arvensis as Components of Scientific Jamu

Cited by 3 publications

References 3 publications

Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria

Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria

Bioactive Compounds and In Vitro Evaluation of Phyllanthus niruri Extract as Antioxidant and Antimicrobial Activities

Standardization and Gc-MS Analysis of Kersen (Muntingia Calabura L.) Fruit Ethanol Extract as an Herbal Raw Material

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