Abstract:Polymeric nanocarriers have been
extensively used in medicinal
applications for drug delivery. However, intravenous nanocarriers
circulating in the blood will be rapidly cleared from the mononuclear
macrophage system. The surface physicochemical characterizations of
nanocarriers are the primary factors to determine their fate in vivo,
such as evading the reticuloendothelial system, exhibiting long blood
circulation times, and accumulating in the targeted site. In this
work, we develop a series of polyurethane … Show more
“…According to our previous reports, single cationic GQA or anionic TPT polyurethane micelles with short mPEG chains still have good self-assembly ability. 33,37 The influence of the short hydrophilic mPEG chain on the instability of G25T25mE0 and G25T25mE500 can be excluded. These results indicate that the oppositely charged moieties in one polymer chain can impair the action of the GQA surfactant and severely hinder its self-assembly ability and stabilization due to the interchain electrostatic attraction.…”
Section: Characteristics Of Polyurethane Micellesmentioning
confidence: 99%
“…32 In our previous report, we demonstrated that polyurethane micelles bearing an anionic tripeptide could minimize the phagocytosis by macrophages and elimination from the reticuloendothelial system. 33 Meanwhile, cationic gemini quaternary ammonium (GQA), which exhibits superior physicochemical properties attributed to its unique structure with a hydrophilic head group and hydrophobic alkyl chain, usually acts as a surfactant with a low critical micelle concentration (CMC) and improved micellization ability. 34 We also found that the GQA surfactant efficiently improved the cellular uptake and permeability of the cell membrane.…”
Gemini quaternary ammonium (GQA), a type of cationic surfactant, exhibits superior performance to improve the micellization ability and acts as a cell internalization promoter to increase the permeability of the...
“…According to our previous reports, single cationic GQA or anionic TPT polyurethane micelles with short mPEG chains still have good self-assembly ability. 33,37 The influence of the short hydrophilic mPEG chain on the instability of G25T25mE0 and G25T25mE500 can be excluded. These results indicate that the oppositely charged moieties in one polymer chain can impair the action of the GQA surfactant and severely hinder its self-assembly ability and stabilization due to the interchain electrostatic attraction.…”
Section: Characteristics Of Polyurethane Micellesmentioning
confidence: 99%
“…32 In our previous report, we demonstrated that polyurethane micelles bearing an anionic tripeptide could minimize the phagocytosis by macrophages and elimination from the reticuloendothelial system. 33 Meanwhile, cationic gemini quaternary ammonium (GQA), which exhibits superior physicochemical properties attributed to its unique structure with a hydrophilic head group and hydrophobic alkyl chain, usually acts as a surfactant with a low critical micelle concentration (CMC) and improved micellization ability. 34 We also found that the GQA surfactant efficiently improved the cellular uptake and permeability of the cell membrane.…”
Gemini quaternary ammonium (GQA), a type of cationic surfactant, exhibits superior performance to improve the micellization ability and acts as a cell internalization promoter to increase the permeability of the...
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