Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers

Wang, Shihai; Zhou, Yu; Tao, Wangwang; Liu, Jingyi; Chen, Hongxiang; Zhao, Zuyi

doi:10.1007/s00289-021-03931-3

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Polyurethane is an important polymer with good biocompatibility and biodegradability. Furthermore, its molecular structure has easy tailorability, so polyurethane with multi‐functional structure can be conveniently obtained by selecting appropriate materials and fewer synthetic steps 39–41 . In addition, multi‐responsive polymeric micelles can also be obtained by co‐assembled strategy, which can take full advantage of different polymers and simplify the synthetic process 42–47 …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, its molecular structure has easy tailorability, so polyurethane with multi-functional structure can be conveniently obtained by selecting appropriate materials and fewer synthetic steps. [39][40][41] In addition, multi-responsive polymeric micelles can also be obtained by co-assembled strategy, which can take full advantage of different polymers and simplify the synthetic process. [42][43][44][45][46][47] Herein, in order to obtain a kind of anticancer drug delivery carriers with good stability in blood circulation, high cellular uptake, and controlled drug release ability, FA-modified pH/reduction-responsive polyurethane micelles (FPUSN/PUC) were prepared by co-assembly of two polyurethanes with opposite charges (FPUSN and PUC).…”

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confidence: 99%

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Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers

Liu,

Zhao,

Tao

et al. 2024

J of Applied Polymer Sci

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In order to obtain a kind of anticancer drug delivery carriers with good stability in blood circulation, high cellular uptake, and controlled drug release ability, folate‐modified polyurethane with disulfide bonds and amino groups (FPUSN) and polyurethane with carboxyl groups (PUC) were respectively synthesized. FPUSN and PUC could co‐assemble in water to form nanomicelles (FPUSN/PUC) via electrostatic interaction. When the mass ratio of FPUSN to PUC was 12, FPUSN/PUC‐12 micelles had obvious negative‐to‐positive charge‐reversal property with decreasing pH from 7.4 to 5.0. Doxorubicin‐loaded micelles (FPUSN/PUC‐12@DOX) with negative charges showed excellent stability under simulated normal physiological condition. However, the charge‐reversal happened at pH 6.5 and positive charges increased with the pH decrease. When the glutathione concentration was 10 mM, the structure of FPUSN/PUC‐12@DOX micelles was broken. So FPUSN/PUC‐12@DOX micelles exhibited significant acid/reduction‐sensitive drug release properties and then DOX could be rapidly released in simulated tumor intracellular environment. Cellular experimental results demonstrated that FPUSN/PUC‐12 micelles could enhance cellular uptake under acid condition and FPUSN/PUC‐12@DOX micelles had better anti‐proliferation effect against HGC‐27 cells at pH 6.5 than that at pH 7.4 owing to multi‐responsive synergistic effects. Therefore, FPUSN/PUC micelles will have great application potential as drug delivery carriers for enhancing anticancer efficacy.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers

Liu,

Zhao,

Tao

et al. 2024

J of Applied Polymer Sci

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“… 4 In addition, chemotherapy has a fast clearance, low therapeutic efficacy, uncontrolled drug release behavior, and lack of selectivity. 5 Hence, there is an urgent need to develop alternative safer therapies to overcome a multitude of adverse effects affiliated to chemotherapy. Accordingly, the anticancer activities of natural products and their synthetic derivatives have been extensively studied, primarily as chemopreventive and chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer

Badawi¹,

Attia²,

El‐Kersh³

et al. 2022

IJN

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Purpose To design and optimize trans -cinnamic acid-loaded PLGA nanoparticles (CIN-PLGA-NPs) and assess its inhibitory effect on epithelial-mesenchymal transition (EMT) in triple-negative breast cancer. Methods The quality by design approach was used to correlate the formulation parameters (PLGA amount and Poloxamer188 concentration) and critical quality attributes (entrapment efficiency percent, particle size and zeta potential). Design of CIN-PLGA-NPs formulations was done based on central composite response surface design and formulated by nanoprecipitation method. In addition, the optimized CIN-PLGA-NPs formulation was further evaluated for morphology using transmission electron microscopy and in vitro dissolution test. The cytotoxicity of CIN-PLGA-NPs optimized formula in comparison to the free trans -cinnamic acid (CIN-Free) was investigated in vitro using MDA-MB-231, triple-negative breast cancer cells, followed by scratch wound assay for evaluating the impact on the migratory potential of MDA-MB-231 cells. In vivo antitumor activity was evaluated using Ehrlich ascites carcinoma solid tumor animal model where tumor volumes were measured at different time points and necrotic/apoptotic indices were estimated in tumor sections. EMT markers, E- and N-cadherin, were assessed in solid tumors as well. Results The optimized formulation showed entrapment efficiency of 76.98%, particle size of 186.3 nm with a smooth spherical surface and zeta potential of −28.47 mV indicating its stability. Furthermore, CIN-PLGA-NPs optimized formula released 60.8±1.89% of the total CIN-Free within 24 hours compared to 29±1.25% of the raw CIN-Free indicating improved dissolution rate. The optimized formula showed superior cytotoxicity on MDA-MB-231 cells compared to its free counterpart as well as increased wound closure percentage along with reduced tumor size in mice and increased necrotic and apoptotic indices. Tumor levels of E-cadherin and N-cadherin were indicative of EMT inhibition. Conclusion Our findings proved the capability of PLGA nanoparticles in loading trans -cinnamic acid in addition to enhancing its antitumor efficacy in triple-negative breast cancer possibly via inhibiting EMT.

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Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers

Cited by 2 publications

References 27 publications

Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers

Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers

Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer

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