Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Wang, Qianqian; Wang, Lin; Gao, Lingling; Yu, Luofeng; Feng, Wei; Liu, Nian; Xu, Miao; Li, Xiaozhou; Li, Peng; Huang, Wei

doi:10.1039/c9tb00498j

Cited by 26 publications

(21 citation statements)

References 56 publications

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“…In the absence of water, there is only internal hydrogen bonding, which explains the finding that the healing efficiency under aqueous condition is slightly higher than that under anhydrous condition. This further improvement of the healing efficiency may be attributed to the electrostatic interactions between the PAA and the bPEI within the shell when healing under aqueous conditions [28] …”

Section: Resultsmentioning

confidence: 99%

“…This further improvement of the healing efficiency may be attributed to the electrostatic interactions between the PAA and the bPEI within the shell when healing under aqueous conditions. [28] Figure 3c and Figure 3d show the schematic illustration of a simulation of the molecular dynamic (MD) of the selfhealing process of STFMs under anhydrous and aqueous conditions, respectively. The MD calculation procedure and the related parameter values are illustrated in Note S2, and the detailed parameters are shown in Table S2.…”

Section: Analysis Of Self-healing Mechanism and Thermochromic Propert...mentioning

confidence: 99%

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Superstable and Intrinsically Self‐Healing Fibrous Membrane with Bionic Confined Protective Structure for Breathable Electronic Skin

Zhu

et al. 2022

Angewandte Chemie

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Considerable effort has been devoted to the fabrication of electronic skin that can imitate the selfhealing and sensing function of biological skin. Almost all self-healing electronic skins are composed of airtight elastomers or hydrogels, which will cause skin inflammation. Fibrous membranes are ideal materials for preparing highly sensitive breathable electronic skins. However, the development of intrinsically self-healing fibrous membranes with high stability is still a challenge. Here, a novel interface protective strategy is reported to develop intrinsically self-healing fibrous membranes with a bionic confined structure for the first time, which were further assembled into an all-fiber structured electronic skin through interfacial hydrogen bonding. The electronic skin is multifunctional with self-powering, self-healing, breathability, stretchability, and thermochromism functionalities, which is highly promising for application in intelligent wearable sensing systems.

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Section: Resultsmentioning

confidence: 99%

Section: Analysis Of Self-healing Mechanism and Thermochromic Propert...mentioning

confidence: 99%

Superstable and Intrinsically Self‐Healing Fibrous Membrane with Bionic Confined Protective Structure for Breathable Electronic Skin

Zhu

et al. 2022

Angewandte Chemie

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“…Therefore, new technologies are greatly demanded to solve the above‐mentioned disadvantages. So far, researchers have witnessed the advancement of antimicrobial polymer coatings to prevent microorganisms' adhesion and proliferation for combating BAI, by various approaches such as self‐assembly interactions, in situ surface immobilization, chemical vapor deposition, and plasma‐assisted surface grafting . However, the preparation of these coatings usually involves complicated steps, expensive materials, or harsh water/oxygen‐free environment .…”

Section: Methodsmentioning

confidence: 99%

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Feng

et al. 2019

Macromol. Rapid Commun.

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In this work, a novel biomimetic surface‐attachable initiator is successfully synthesized by the conjugation of 3,4‐dihydroxyphenylacetic acid and thermal 2,2′‐azobis(2‐methylpropionamide) dihydrochloride (V‐50). The synthesized initiator (DOPV) can adhere to various material surfaces in a mussel‐inspired way and initiate the surface grafting polymerization. Hydrogel coatings are facilely prepared by the thermal‐initiated radical copolymerization of antimicrobial polyhexamethylene guanidine and antifouling polyethylene glycol oligomers. The developed hydrogel coatings not only show antimicrobial activity toward gram‐negative and gram‐positive bacteria but also demonstrate protein resistance, antibiofilm efficacy, hemocompatibility, and low cytotoxicity in vitro. Most importantly, the hydrogel coatings reveal excellent antimicrobial efficacy with a log reduction above 5 in a rodent subcutaneous infection model. These results demonstrate the potential fabrication of bio‐functional coatings for biomedical devices or implants through an inexpensive, facile, and environmentally friendly mussel‐inspired technique.

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“…4,[9][10][11][12][13][14][15][16] In particular, LbL films can be used as both bacterial adhesion resistant and bactericidal systems. 2,3,6,[17][18][19][20][21] It is well known that LbL coatings are widely used for altering the surface properties, such as wettability, roughness, surface charge, mechanical characteristics, and so on. In general, the properties of the substrate surface also affect the bacterial adhesion; therefore, LbL technique can be used to create systems with resistance to bacterial adhesion.…”

mentioning

confidence: 99%

“…related infections originating from pathogenic microorganism adhesion and subsequent formation of biofilm on the surface. [2][3][4][5][6] To solve the problems caused by bacterial growth on the medical implants, their surface can be covered by antibacterial coatings. There are two main strategies for the development of antimicrobial coatings.…”

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confidence: 99%

Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential

Kulikouskaya

Zhdanko

Hileuskaya

et al. 2021

J Biomedical Materials Res

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Implant-related infection is one of the serious problems in regenerative medicine.Promising approach to overcome the problems caused by bacterial growth on the medical implants is their modification by bioactive coatings. A versatile technique for designing multilayer films with tailored characteristics at the nanometer scale is layer-by-layer assembly. In this study, multilayer films based on biopolymers (pectin and chitosan) and their nanocomposites with silver nanoparticles have been prepared and evaluated. The buildup of multilayers was monitored using the quartz crystal microbalance with dissipation technique. The morphology of the obtained films was investigated by atomic force microscopy. We have demonstrated that pectin-Agcontaining films were characterized by the linear growth and smooth defect-free surface. When pectin-Ag was substituted for the pectin in the multilayer systems, the properties of the formed coatings were significantly changed: the film rigidity and surface roughness increased, as well as the film growth acquired the parabolic character. All prepared multilayer films have shown antibacterial activity against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria.The significant decrease in the number of the adhered E. coli on the multilayer surface has been determined; moreover, many of the cells were misshapen with cytoplasm leaking. The prepared multilayer films showed a mild activity against S. aureus predominantly due to the antiadhesive effect. Our results indicate that antibacterial activity of biopolymer multilayers is determined by the film composition and physicochemical characteristics and can be associated with their antiadhesive and bactericidal behaviors.

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Stable and self-healable LbL coating with antibiofilm efficacy based on alkylated polyethyleneimine micelles

Abstract: An antibacterial and self-healing coating was fabricated via LbL assembly based on N-decyl PEI (DPEI) micelles.

Cited by 26 publications

References 56 publications

Superstable and Intrinsically Self‐Healing Fibrous Membrane with Bionic Confined Protective Structure for Breathable Electronic Skin

Superstable and Intrinsically Self‐Healing Fibrous Membrane with Bionic Confined Protective Structure for Breathable Electronic Skin

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Physicochemical aspects of design of ultrathin films based on chitosan, pectin, and their silver nanocomposites with antiadhesive and bactericidal potential

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