Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Abstract

In this work, a novel biomimetic surface‐attachable initiator is successfully synthesized by the conjugation of 3,4‐dihydroxyphenylacetic acid and thermal 2,2′‐azobis(2‐methylpropionamide) dihydrochloride (V‐50). The synthesized initiator (DOPV) can adhere to various material surfaces in a mussel‐inspired way and initiate the surface grafting polymerization. Hydrogel coatings are facilely prepared by the thermal‐initiated radical copolymerization of antimicrobial polyhexamethylene guanidine and antifouling polyethylene glycol oligomers. The developed hydrogel coatings not only show antimicrobial activity toward gram‐negative and gram‐positive bacteria but also demonstrate protein resistance, antibiofilm efficacy, hemocompatibility, and low cytotoxicity in vitro. Most importantly, the hydrogel coatings reveal excellent antimicrobial efficacy with a log reduction above 5 in a rodent subcutaneous infection model. These results demonstrate the potential fabrication of bio‐functional coatings for biomedical devices or implants through an inexpensive, facile, and environmentally friendly mussel‐inspired technique.

Gold@Halloysite nanotubes-chitin composite hydrogel with antibacterial and hemostatic activity for wound healing

“…So, HNTs were usually mixed with polymer matrix or coated on polymer fiber surface to prepare composite dressing [ 19 ]. As a wound dressing, hydrogel materials have many advantages, which can not only seal the wound blood vessels to achieve the purpose of hemostasis [ 20 , 21 ] but also provide a moist environment to prevent infection and accelerate wound healing [ 22 , 23 ]. In addition, the hydrogel has certain toughness, softness and flexibility, which enables the hydrogel better covering on wounds in different parts.…”

One-step vapor deposition of fluorinated polycationic coating to fabricate antifouling and anti-infective textile against drug-resistant bacteria and viruses

“…This spread of infection could be prevented if the surfaces are coated with antimicrobial polymers. Generally, the antimicrobial polymeric coatings are designed based on two strategies: antifouling and killing [12] , [13] , [14] , [15] , [16] . The prevention of contaminant adhesion on surfaces could efficiently inhibit pathogen infections [17] .…”

Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

“…Layer-by-layer self-assembly (LBL) [14] and the sol-gel method [15] are common methods for preparing polymer coatings. Hydrogels not only possess viscoelasticity, low toxicity, and biocompatibility [16,17], but their unique swelling properties are conducive to sustained drug release. Thus, using them is an effective strategy to form a composite antibacterial coating.…”

“…Recently, mussel-inspired chemistry has shown great potential to build a convenient adhesion of biopolymer to the solid substrate [16,20]. Extensive studies have certified that catechol motifs contribute to strong adhesion [21].…”