Stability studies on some benzocycloheptane antihistaminic agents

Abounassif, Mohammad A.; El-Obeid, Humeida A.; Gadkariem, Elrasheed A.

doi:10.1016/j.jpba.2004.09.019

Cited by 24 publications

(23 citation statements)

References 20 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, ketotifen is a relatively selective, noncompetitive antagonist of histamine H1 receptors and is a mast cell stabilizer, inhibiting the release of inflammatory mediators from mast cells [1, 2, 5]. Ketotifen fumarate was determined using spectrophotometric [6–10], chromatographic [11–15], and electroanalysis methods [16–19].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

Frag

Khalil

Hwehy

2011

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7 to 10−2 mol L−1. The electrodes show Nernstian slope value of 52.51 ± 0.20 and 51.51 ± 0.25 mV decade−1 for CPE and PVC membrane electrodes at 30°C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of 98.97 ± 0.53 and 98.62 ± 0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.

show abstract

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

Frag

Khalil

Hwehy

2011

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

show abstract

“…It is chemically known as 9,10-dihydro-4-(1-methylpiperidin-4-ylidene)-4H-benzo [4,5]cyclohepta [1,2-b]thiophene hydrogen maleate ( Figure 1) [1]. It also antagonises the action of tryptamine.…”

Section: Introductionmentioning

confidence: 99%

“…Several analytical methods have been reported for the determination of PZT in pure drug, pharmaceutical dosage forms and biological samples using high performance liquid chromatography [3][4][5][6][7], spectrofluorimetry [8] and two spectrophotometric methods [8,9]. All the above reported methods developed for the determinationof PZT employed complex analytical techniques, complicated, expensive, require careful control of conditions or skilled personnel and are inaccessible to many laboratories.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric determination of pizotefin maleate in pure form and tablets using π-acceptors

Amin¹,

Gouda²,

Sheikh³

et al. 2015

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT. Two simple, quick and sensitive methods were described for the spectrophotometric determination of pizotefin maleate (PZT) either in pure form or pharmaceutical form (tablets). The methods were based on the reaction of pizotefin maleate as 'n' electron donor with chloranilic acid (p-CLA) and 7,7,8, as π-acceptors to give highly coloured radical anion species which were quantitated spectrophotometrically at 533 and 839 nm for chloranilic acid and 7,7,8,8-tetracyanoquinodimethane, respectively. Different experimental conditions for the two methods were optimized. Beer's law was obeyed in the concentration ranges of 10-160 and 2.0-20 g mL -1 PZT for p-CLA and TCNQ, respectively with good correlation coefficient of ≥0.9993 and a relative standard deviation (RSD) of ≤ 1.31%. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also reported. The proposed methods were successfully applied for determination of PZT in tablets with good accuracy and precision and without interferences from common additives by applying the standard addition technique. The developed methods have been validated statistically for their accuracy, precision, sensitivity, selectivity, robustness and ruggedness as per ICH guidelines and the results compared favourably with those obtained using the reported method.

show abstract

“…The drug is official in British Pharmacopoeia [4], which describes a potentiometric titration with perchloric acid in acetic anhydride-acetic acid medium. The therapeutic importance of the drug has prompted the development of a variety of techniques for its assay in pharmaceuticals and body fluids.…”

Section: Introductionmentioning

confidence: 99%

Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents

Raghu

Basavaiah

Prashanth

et al. 2013

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drug and in tablets using cerium(IV) as the oxidimetric agent. In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II). The spectrophotometric procedures involve addition of a known excess of cerium(IV) to KTF in acid medium followed by the determination of unreacted oxidant by reacting with either p-dimethyl amino benzaldehyde and measuring the resulting colour at 460 nm (method B) or o-dianisidine and subsequent measurement of the absorbance of coloured product at 470 nm (method C). Titrimetric assay is based on a 1 : 2 reaction stoichiometry between KTF and cerium(IV) and the method is applicable over 2–18 mg range. In spectrophotometry, regression analysis of Beer's law plots showed a good correlation in 0.4–8.0 and 0.4–10.0 g mL−1 KTF ranges for method B and method C, respectively, and the corresponding molar absorptivity coefficients are calculated to be 4.0 × 104 and 3.7 × 104 L mol−1 cm−1.

show abstract

Stability studies on some benzocycloheptane antihistaminic agents

Cited by 24 publications

References 20 publications

Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

Spectrophotometric determination of pizotefin maleate in pure form and tablets using π-acceptors

Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents

Contact Info

Product

Resources

About