Spectrophotometric determination of pizotefin maleate in pure form and tablets using π-acceptors

Amin, Alaa S.; Gouda, Ayman A.; Sheikh, Ragaa El; Youssef, Eman H.

doi:10.4314/bcse.v29i2.3

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…The creation of brightly coloured charge transfer complexes, which absorb visible radiation, is often connected with molecular interactions between electron donors and acceptors [30]. Charge-transfer complexes with diverse acceptors have been reported using a variety of electron-donating chemicals [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Methods for the Quantitative Determination of Memantine Hydrochloride in Pure Form and Pharmaceutical Formulations

et al. 2022

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Objective: Three simple, sensitive, accurate, and precise spectrophotometric methods have been developed and validated for the determination of Alzheimer’s disease drug memantine HCl (MEM) in pure form and pharmaceutical formulations. Methods: The method was based on the formation of charge transfer complex between MEM as n-electron donor and various π-acceptors quinalizarin (Quinz) in methanol, p-chloranilic acid (p-CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) in acetonitrile as chromogenic reagents which showed an absorption maximum at 558, 532 and 840 nm using Quinz, p-CA and TCNQ, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Results: Under the optimum conditions, beer’s law is obeyed in the concentration ranges 4.0–24, 10–160 and 5.0–50 μg/mlusing Quinz, p-CA and TCNQ, respectively with good correlation coefficient (r2 ≥ 0.9995) and with a relative standard deviation (RSD% ≤ 1.11). For more accurate analysis, Ringbom optimum concentration ranges were found to be between 8.0–20, 15–140 and 10–45 μg/ml using Quinz, p-CA and TCNQ, respectively. The limits of detection were found to be 1.2, 2.70 and 1.45 µg/ml and the limits of quantification were found to be 4.0, 9.0 and 4.83 µg/ml for Quinz, p-CA and TCNQ, respectively. A Job's plot of the absorbance versus the molar ratio of MEM to each of the acceptors under consideration indicated (1:1) ratio. Conclusion: The methods were successfully applied to the determination of MEM in its pharmaceutical formulations and the validity assessed by applying the standard addition technique. Results obtained by the proposed methods for the pure MEM and commercial tablets agreed well with those obtained by the reported method.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric Methods for the Quantitative Determination of Memantine Hydrochloride in Pure Form and Pharmaceutical Formulations

et al. 2022

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“…A variety of electron donating compounds have been reported to yield charge-transfer complexes with various acceptors. The rapid formation of these complexes leads to their utility in the development of simple and convenient spectrophotometric methods for these compounds [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric methods based on charge transfer complexation reaction for the determination of some antifungal drugs in pure and dosage forms

Gouda¹,

Sheikh²,

Amin³

et al. 2017

Bull. Chem. Soc. Eth.

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ABSTRACT. Charge transfer complexes of some antifungal drugs fluconazole (FLU), sertaconazole nitrate (SER) and miconazole nitrate (MCO) as electron donor with the σ-acceptor iodine (I2) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), p-chloranilic acid (p-CLA) and 7,7,8, as π-acceptors in acetonitrile were investigated. The formation of the colored charge-transfer complexes were utilized in the development of simple, rapid and accurate spectrophotometric methods for the analysis of the cited drugs in pure forms and pharmaceutical formulations at 365 nm for MCO and SER using I2 method, at 460 nm for FLU and SER using DDQ method, at 535 and 530 nm for FLU and SER, respectively, using p-CLA method and at 842 nm for MCO and SER using TCNQ method. The optimum experimental conditions have been studied carefully and optimized. Beer's law was obeyed over the concentration ranges of 2.0-28, 10-240 and 2.0-160 µg mL −1 for MCO, FLU and SER, respectively, with good correlation coefficients (0.9996-0.9999). Molar absorpitivity, Sandell sensitivity, relative standard deviation, limit of detection and quantification were calculated. The obtained data refer to high accuracy and precision of the proposed method. The obtained results were confirmed by inter and intra-day accuracy and precision with percent recovery of 99.1-100%, 99.3-101% and 99.1-101% for MCO, FLU and SER, respectively. These data were compared with those obtained using official methods for the determination of the cited drugs. The proposed methods were applied successfully for simultaneous determination of the cited drugs in their pharmaceutical formulations with good accuracy and precision and without interferences from common additives.

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Spectrophotometric determination of pizotefin maleate in pure form and tablets using π-acceptors

Cited by 2 publications

References 9 publications

Spectrophotometric Methods for the Quantitative Determination of Memantine Hydrochloride in Pure Form and Pharmaceutical Formulations

Spectrophotometric Methods for the Quantitative Determination of Memantine Hydrochloride in Pure Form and Pharmaceutical Formulations

Spectrophotometric methods based on charge transfer complexation reaction for the determination of some antifungal drugs in pure and dosage forms

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