Stability studies on florfenicol using developed derivative spectrophotometric methods

Elimam, Mohammed Mutasim; Shantier, Shaza W.; Gadkariem, Elrasheed A.; Mohamed, Magdi A.; Osman, Zuheir

doi:10.1016/j.pharma.2016.07.003

Cited by 8 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of derivative spectroscopy provided simple and accurate tool for the analysis and stability studies of different pharmaceutical dosage forms [25][26][27][28] .…”

Section: Resultsmentioning

confidence: 99%

Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Ranolazine in Bulk and Dosage Forms

KMAİL¹,

Shantier²,

Gadkariem³

2022

Hacettepe University Journal of the Faculty of Pharmacy

View full text Add to dashboard Cite

The present study was aimed to develop simple and accurate derivative spectrophotometric methods ( 1 D and 2 D) for the assay and stability studies of Ranolazine (RAN) in bulk and dosage forms. The methods were based on differentiating the original UV spectrum of RAN solution in methanol to generate the first and second derivative spectra which were measured at 278nm and 283 nm, respectively. The developed methods were then validated as per ICH guidelines and applied for the stability studies. Beer's law was found to be valid over the concentration range100-600 µg/ml with correlation coefficient (r) not less than 0.999. The obtained limit of detection (LOD) and limit of quantification (LOQ) reflected the sensitivity of the methods (24.0 µg/ ml and 73.0 µg/ ml, 17.8 µg/ ml and 53.6 µg/ ml, for 1 D and 2 D, respectively). Good results were also obtained from the assay of RAN tablets (98.6 ± 2.3%, n=3). Studying the stability behavior of RAN using the developed methods reflects its instability under alkaline conditions following the first-order kinetics. The statistical validation at a 95% confidence level proves the sensitivity, precision, accuracy, and stability-indicating properties of the developed methods.

show abstract

“…The development of derivative spectroscopy provided simple and accurate tool for the analysis and stability studies of different pharmaceutical dosage forms [25][26][27][28] .…”

Section: Resultsmentioning

confidence: 99%

Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Ranolazine in Bulk and Dosage Forms

KMAİL¹,

Shantier²,

Gadkariem³

2022

Hacettepe University Journal of the Faculty of Pharmacy

View full text Add to dashboard Cite

show abstract

“…Preserved duck eggs are made from fresh duck eggs wrapped with a mixture of clay, ash, salt, quick‐lime, and rice hulls over a period of several weeks to months before on sale, depending on the production methods (Li et al., 2017). A study provided evidence that alkaline conditions could dramatically decrease florfenicol content (Elimam et al., 2017). So alkaline conditions (a mixture of clay) created for preserved eggs could attribute to the fact that fewer antibiotics are detected in them than that in salted duck eggs.…”

Section: Resultsmentioning

confidence: 99%

Multiresidue determination of antibiotics in ready‐to‐eat duck eggs marketed through e‐commerce stores in China and subsequent assessment of dietary risks to consumers

Ji¹,

Wang³

et al. 2021

Journal of Food Science

View full text Add to dashboard Cite

In this work, the occurrence of 34 common antibiotic (15 sulfonamides and 19 quinolones) residues were evaluated in 236 ready‐to‐eat duck eggs (salted and preserved duck eggs) marketed through e‐commerce stores by ultra‐performance liquid chromatography coupled to tandem mass spectrometry, and subsequent dietary risk assessments for Chinese consumers were conducted. Among violated positives in duck egg samples, 11 analytes were found including sulfamethazine, sulfaquinoxaline, sulfamethoxazole, sulfadiazine, sulfamonomethoxine, ciprofloxacin, enrofloxacin, ofloxacin, flumequine, sarafloxacin, and nalidixic acid. A higher number of antibiotics were detected in salted duck eggs (five sulfonamides and six quinolones) than in preserved duck eggs (one sulfonamide and two quinolones). The maximum contamination of sulfonamides and quniolones was 448.0 µg/kg (sulfaquinoxaline) and 563.7 µg/kg (enrofloxacin) in salted duck eggs, respectively. Dietary exposure was evaluated through the estimated daily intake (EDI) of risky antibiotics (sulfamethazine, ciprofloxacin, and enrofloxacin) and hazard quotients (HQs). The results showed that EDIs and HQs were in the range of 0.0004 to 0.0099 µg/kg bw/day and 0.0009 to 0.1594%, respectively. The risk was low since HQs obtained were less than 100%. However, a special attention should be paid to ready‐to‐eat duck egg products high percentile consumers with the prosperity of e‐commerce market in China. Practical Application The present analytical method could be used for multiresidue determination of antibiotics in ready‐to‐eat duck eggs, and dietary risk assessments of risky antibiotics provided a support for the work of regulatory bodies to conduct surveillance programs regarding food safety evaluation of ready‐to‐eat foods.

show abstract

“…Florfenicol is an amide containing drug which is liable to chemical degradation. Referring to the stability studies conducted on florfenicol 8…”

Section: Resultsmentioning

confidence: 99%

“…[3][4][5][6] , which have been applied mainly for its analysis in biological fluids. Recently, we developed simple and accurate methods for its analysis and stability studies in pharmaceutical dosage form 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Differential Spectrophotometric Method for Determination of Florfenicol

2016

Chem Sci Trans

View full text Add to dashboard Cite

Simple, selective and accurate differential first derivative spectrophotometric method (∆D 1) was developed for the determination of florfenicol in bulk and pharmaceutical formulation. The developed method was based on measuring the ∆D 1 of florfenicol in alkaline solutions against its aqueous solutions as blank. Beer's law was found to be linear over the concentration range 3-15 µg/mL with good correlation coefficient (0.999). The selectivity of the method was proved through freedom from interferences.

show abstract

Stability studies on florfenicol using developed derivative spectrophotometric methods

Cited by 8 publications

References 9 publications

Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Ranolazine in Bulk and Dosage Forms

Derivative Spectrophotometric Methods for the Analysis and Stability Studies of Ranolazine in Bulk and Dosage Forms

Multiresidue determination of antibiotics in ready‐to‐eat duck eggs marketed through e‐commerce stores in China and subsequent assessment of dietary risks to consumers

Differential Spectrophotometric Method for Determination of Florfenicol

Contact Info

Product

Resources

About