Stability of Andrographolide in Powdered Andrographis Herb under Accelerated Conditions

Abstract

The stability of andrographolide in powdered Andrographis Herb--the aerial part of Andrographis paniculata (Burm. f.) Nees (Acanthaceae)--was determined using a heat-accelerated experiment to reveal a second-order kinetics of degradation. The fast decomposition was observed regardless of the method of analysis. The rate constant of the decomposition of andrographolide at 25 degrees C ( K(25)( degrees C)), predicted from the Arrhenius plot, was 6.58 x 10 (-6) d (-1).

FT-IR spectra and vibrational spectroscopy of Andrographolide

“…Though some older studies suggested andrographis was antibacterial, modern research has been unable to confirm this finding [4]. Although, a number of studies on the structure and stability of andrographolide have been carried out [5][6][7][8][9]. To the best of our knowledge no study on the normal coordinate analysis on andrographolide has been reported so far in the literature.…”

STABILITY AND TOXICITY PROFILE OF SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS (SEDS) FORMULATED Andrographis paniculata EXTRACT

“…In spite of the capability of in minimizing undesirable changes during the transformation process, the stability of bioactive compounds in the final dry extract is equally important to preserve good quality of the dry extract. Studies related to the stability of andrographolide from different formulations such as those in powdered A. paniculata, aqueous A. paniculata extract, isolated andrographolide from A. paniculata extract, solid dispersion in polyvinylpyrrolidone (PVP-K30) as well as solid dispersion in silicon dioxide (SiO 2 ) have been conducted and reported (Ibrahim and Chong, 2008;Lomlim et al, 2003;Pholphana et al, 2004;Plubrukarn et al, 2006;Wongkittipong et al, 2004;Zhang et al, 2016). Thus far, first and secondorder kinetics of degradation of andrographolide have been reported (Lomlim et al, 2003;Plubrukarn et al, 2006;Wongkittipong et al, 2004).…”

“…Studies related to the stability of andrographolide from different formulations such as those in powdered A. paniculata, aqueous A. paniculata extract, isolated andrographolide from A. paniculata extract, solid dispersion in polyvinylpyrrolidone (PVP-K30) as well as solid dispersion in silicon dioxide (SiO 2 ) have been conducted and reported (Ibrahim and Chong, 2008;Lomlim et al, 2003;Pholphana et al, 2004;Plubrukarn et al, 2006;Wongkittipong et al, 2004;Zhang et al, 2016). Thus far, first and secondorder kinetics of degradation of andrographolide have been reported (Lomlim et al, 2003;Plubrukarn et al, 2006;Wongkittipong et al, 2004). High storage temperature such as 45 to 70 C and 86 to 97 C resulted in degradation of andrographolide and the degree of degradation increased with temperature (Lomlim et al, 2003;Plubrukarn et al, 2006;Wongkittipong et al, 2004), while lower storage temperatures such as 5 to 30 C caused no significant reduction of andrographolide along the study period (Ibrahim and Chong, 2008).…”

Stability-indicating TLC—image analysis method for determination of andrographolide in bulk drug and Andrographis paniculata formulations

“…Since A. paniculata plant and formulations have been widely used as a common herbal drug for the treatment of colds, flu and uncomplicated respiratory infections, an investigation on the stability of its major active constituent, andrographolide, would be of interest. There were a few reports on a stability study of andrographolide under selected conditions using HPLC as the analytical method [15,16]. However, none of them is a stabilityindicating method.…”