FT-IR spectra and vibrational spectroscopy of Andrographolide

Abstract

A complete normal coordinate analysis was performed for andrographolide in terms of the calculation by using Wilson's G-F matrix method and Urey Bradley force field. Normal coordinate analysis has been carried out to understand the dynamical behaviour of the bioactive labdane diterpenoid of the medicinally useful terrestrial plant Andrographis paniculata. The structural elucidation of a novel, biologically active natural product followed by its total synthesis lays the groundwork for investigations into its biological mechanism of action including putative cellular receptor isolation.

A Validated Fourier Transform Infrared Spectroscopy Method for Quantification of Total Lactones in Inula racemosa and Andrographis paniculata

“…Andrographolide, another compound discussed in this paper, has shown hepatoprotective, choleretic and hypoglycemic activities (Dev, 2006). There are methods reported for isolation and structure elucidation of andrographolide from Andrographis paniculata (Singh et al, 2006).…”

Vibrational and Quantum Chemical Study of Triphenylantimony (V) Benzilate SbPh3 [O2CC (OH) Ph2]2

“…We have used Urey Bradley force field [9] in our calculations, which takes into account both bonded, and nonbonded interactions and internal tensions. For the assignments, the force constants were initially transferred from our earlier work and literature [13][14][15][16][17][18][19][20] and were further refined by least square fit method to provide best match with the observed FT-IR spectra. In the assignment of the normal modes, as given in Table I, only the dominant potential energies distributions (PED's) are considered.…”

Normal coordinate analysis and quantum chemical study of tris(p-fluorophenyl)antimony di(N-phenylglycinate) [(p-FC6H4)3Sb(O2CCH2NHC6H5)2]

“…In the assignment of the normal modes, as given in table 1, only the dominant potential energy distributions (PEDs) are considered. Identification with the experimental data has been made on the basis of potential energy distribution, line profile, line intensities and the presence/absence of a given mode in similar molecules [12,18,19].…”