Stability constants of mixed ligand complexes of vanadium(III) with 8-hydroxyquinoline and the amino acids glycine, proline, α-alanine and β-alanine

Sanoja, William; Martínez, José Daniel; Araujo, Mary Lorena; Brito, Felipe; Hernández, Lino; Carpio, Edgar Del; Lubes, Vito

doi:10.1016/j.molliq.2014.05.012

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…This protein was selected due to their reported studies [17,18], which revealed that theses complexes can bind to the DNA gyrase and could be considered as biologically active compound [19]. Additionally, the synthesized complexes were screened in vitro for antimicrobial activity and were subjected to theoretical molecular docking evaluation [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

et al. 2021

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The synthesis of mixed-ligand complexes is considered an important strategy for developing new metal complexes of enhanced biological activity. This paper presents the synthesis, characterization, in vitro antimicrobial assessment, and theoretical molecular docking evaluation for synthesized oxidovanadium (V) complexes. The proposed structures of the synthesized compounds were proved using elemental and different spectroscopic analysis. The antimicrobial tests showed moderate activity of the compounds against the Gram-positive bacterial strains and the fungal yeast, whereas no activity was observed against the Gram-negative bacterial strains. The performance of density functional theory (DFT) was conducted to study the interaction mode of the targeted compounds with the biological system. Calculating the quantitative structure-activity relationship (QSPR) was performed depending on optimization geometries, frontier molecular orbitals (FMOs), and chemical reactivities for synthesized compounds. The molecular electrostatic potentials (MEPs) that were plotted link the interaction manner of synthesized compounds with the receptor. The molecular docking evaluation revealed that the examined compounds may possess potential antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

et al. 2021

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“…Vanadium compounds are known to possess insulin mimetic activity, inhibit lipolysis, decrease blood glucose levels (BGL) in animals and in clinical trials, and stimulate insulin secretion in experimental models of Diabetes Mellitus (DM) [5][6][7][8][9][10]. 8-hydroxyquinoline is monoprotic bidentate ligand and is widely used in complex formation [11]. 8-hydoxyquinoline and its metal complexes exhibit antiseptic, disinfectant and pesticide properties [12].…”

Section: Introductionmentioning

confidence: 99%

New Oxidovanadium(IV) Mixed Ligand Complexes: Antidibetic, Anticancer activities and Cytotoxicity Study Using MTT Assay

Gayakwad

Wankhede

Ragole

et al. 2021

Preprint

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Five new (HQ-1 to HQ-5) oxidovanadium(IV) mixed ligand complexes using 8-hydroxyquinoline as primary ligand and amino acids like L-cystein, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands in 1:1:1 ratio were synthesized. All the complexes were characterized using various characterization techniques such as elemental analysis, IR, electronic, mass spectra, thermal (TGA/DTA) and powder XRD analysis, molar conductance and magnetic susceptibility measurements. Based on the results obtained all the complexes were proposed to have square pyramidal geometry. All the complexes were screened for their antibacterial activities against E. coli and antifungal activities against C. albicans. In vitro antidibetic activities of all the complexes were studied by screening them for a-amylase inhibition activities. The complexes HQ-4 and HQ-5 were also screened for their anticancer activities against human cancer cells HepG2 using MTT assay.

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“…8-hq and their derivatives represent an interesting class of compounds possessing a wide spectrum of biological activities such as antifungal, anticancer, anti-inflammatory, antibacterial properties and antitumor [16][17][18][19][20] activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

Thamilarasan

Sengottuvelan

Sudha

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Stability constants of mixed ligand complexes of vanadium(III) with 8-hydroxyquinoline and the amino acids glycine, proline, α-alanine and β-alanine

Cited by 8 publications

References 9 publications

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

Preparation, Antimicrobial Activity and Docking Study of Vanadium Mixed Ligand Complexes Containing 4-Amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol and Aminophenol Derivatives

New Oxidovanadium(IV) Mixed Ligand Complexes: Antidibetic, Anticancer activities and Cytotoxicity Study Using MTT Assay

Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

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