Five new (HQ-1 to HQ-5) oxidovanadium(IV) mixed ligand complexes using 8-hydroxyquinoline as primary ligand and amino acids like L-cystein, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands in 1:1:1 ratio were synthesized. All the complexes were characterized using various characterization techniques such as elemental analysis, IR, electronic, mass spectra, thermal (TGA/DTA) and powder XRD analysis, molar conductance and magnetic susceptibility measurements. Based on the results obtained all the complexes were proposed to have square pyramidal geometry. All the complexes were screened for their antibacterial activities against E. coli and antifungal activities against C. albicans. In vitro antidibetic activities of all the complexes were studied by screening them for a-amylase inhibition activities. The complexes HQ-4 and HQ-5 were also screened for their anticancer activities against human cancer cells HepG2 using MTT assay.
Introduction:
Cancer and diabetes are proving to be lethal to human society and have attracted attention of researchers around the world. Synthesis of mixed ligand complexes is a challenging area owing to their potential applications as drugs against various diseases.
Methods:
Synthesis and biological evaluation of mixed ligand complexes of Vanadium(IV) with heterocyclic bidentate molecule 8-hydroxyquinoline as primary ligand and L-Amino acids such as L-cysteine, L-alanine, L-phenylalanine, L-threonine and L-serine as secondary ligands is reported here. All the complexes were characterized using IR, electronic, Mass, TGA/DTA method, powder XRD analysis, molar conductance and magnetic susceptibility measurements and were screened for their biological activities.
Results:
The synthesized mixed ligand complexes were screened for their antibacterial activity against E. Coli and antifungal activity against C. Albicans. They were also evaluated for in vitro antidiabetic activity, anticancer activity against HepG2 (human liver cancer cell line) by MTT assay.
Conclusion:
The synthesized mixed ligand complexes were thermally stable, paramagnetic, non-electrolytic in nature and proposed to have square pyramidal geometry. They also exhibited potential as antibacterial, anticancer and antidibetic agents.
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