Journal of Cell Biology volume 217, issue 4, P1335-1351 2018 DOI: 10.1083/jcb.201708064 View full text
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Xiang Wang, Xiaofan Wei, Yang Yuan, Qingrui Sun, Jun Zhan, Jing Zhang, Yan Tang, Feng Li, Lihua Ding, Qinong Ye, Hongquan Zhang

Abstract: Wang et al. unveil a new mechanism by which Src may function as an oncogene. Phosphorylation of FHL1 by Src triggers the translocation of FHL1 to the nucleus, where it regulates the activity of the transcription factor BCLAF1 to promote tumor cell growth and loses the ability to regulate cell adhesion and suppress growth.