Study reveals that protein regulates spindle microtubule dynamics by inhibiting microtubule depolymerase MCAK.

Although many factors have been implicated in the docking steps that precede vesicle fusion with a target membrane, few similarities have been found between them. New evidence suggests that at least some of these factors form related multimeric complexes that may help to explain the mechanism of vesicle docking.

No abstract

High-throughput omics technologies generate huge datasets on the protein, transcript, lipid, and metabolite content of cells. By integrating and analyzing these data, systems biologists study complex networks of physical and functional interactions that go beyond the traditional focus on individual proteins or linear pathways. Many cell biologists have greeted these developments with healthy skepticism, complaining that long lists of genes or “hairballs” of interactions provide little insight into biological questions of genuine meaning. As omics techniques move beyond acquisition into hypothesis-driven applications, the chasm between systems biologists and cell biologists is narrowing and the benefits of working together are increasingly clear. While cell biologists need omics and computer analyses to extend their understanding of biological processes, omics scientists need cell biologists to help them interpret and use their vast amounts of data.

In 1992, Gavrieli et al. described a new assay to detect cell death in vivo.

No abstract

Organotypic cultures help to unravel how a transcription factor modulates crosstalk between different layers of the skin.

Photobleaching reveals that the backbone of muscle myofibrils is surprisingly mobile.