Squaric acid: an impressive organocatalyst for the synthesis of biologically relevant 2,3-dihydro-1H-perimidines in water

Khopkar, Sushil; Shankarling, Ganapati S.

doi:10.1007/s12039-019-1735-1

Cited by 15 publications

(3 citation statements)

References 33 publications

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“…Electron-decient aromatic ketones, such as 10a containing nitro group, nished the process in 30 min resulting in a 96% yield, whereas electron-rich ones, such as 4-methoxy acetophenone, required 105 min with an 86% yield. 106 2.4.2. Synthesis of polyester.…”

Section: Squaric Acid Catalyzed Reactionsmentioning

confidence: 99%

Advances in organocatalyzed synthesis of organic compounds

Zafar,

Iqbal,

Iram

et al. 2024

RSC Adv.

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Section: Squaric Acid Catalyzed Reactionsmentioning

confidence: 99%

Advances in organocatalyzed synthesis of organic compounds

Zafar,

Iqbal,

Iram

et al. 2024

RSC Adv.

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“…Khopkar et al [81] reported an efficient catalyst, squaric acid, for the synthesis of perimidines from NDA and ketone in water at 80 °C. Squaric acid is a green dibasic organocatalyst possessing high selectivity, water solubility, and reusability.…”

Section: Scheme 5 Acid-catalyzed Perimidine Synthesis In Different Comentioning

confidence: 99%

Recent Advances in the Synthesis of Perimidines and their Applications

Sahiba¹,

Agarwal²

2020

Top Curr Chem (Z)

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Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.

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“…HBOB, PTSA, BF 3 -H 2 O, chitosan hydrochloride, squaric acid, sulfamic acid, etc. were used for the synthesis of this moiety [18][19][20][21][22][23][24][25][26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

Metal Free Sulfonic Acid Functionalized Carbon Catalyst for Green and Mechanochemical Synthesis of Perimidines

Sahiba¹,

Sethiya²,

Soni³

et al. 2020

ChemistrySelect

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A new and scalable mechanochemical approach has been developed for the synthesis of perimidine derivatives using an efficient and recyclable catalyst, carbon sulfonic acid under metal-free conditions. A wide variety of aldehydes displayed cyclo-condensation reaction with 1,8-diaminonaphthalene in EtOH under ambient reaction conditions via grind-stone technique to produce substituted perimidines in excellent yields (95-99 %) in a very short reaction time. This method has interesting features like single-step synthesis, high functional group tolerance, transition-metal free synthesis, high atomeconomy, recyclable catalyst, no need of tedious purification process, gram-scale synthesis, high green chemistry matrix (Eco-score and E-factor) that make this protocol green and ecofriendly.

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Squaric acid: an impressive organocatalyst for the synthesis of biologically relevant 2,3-dihydro-1H-perimidines in water

Cited by 15 publications

References 33 publications

Advances in organocatalyzed synthesis of organic compounds

Advances in organocatalyzed synthesis of organic compounds

Recent Advances in the Synthesis of Perimidines and their Applications

Metal Free Sulfonic Acid Functionalized Carbon Catalyst for Green and Mechanochemical Synthesis of Perimidines

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