Squamous cell carcinoma of bladder after successful intravesical therapy with bacillus calmette-guérin

Brenner, David; Yore, Lawrence; Schellhammer, Paul

doi:10.1016/0090-4295(89)90171-4

Cited by 13 publications

(11 citation statements)

References 18 publications

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“…17 Other studies have documented a greater risk for SCC of the bladder after intravesical immunotherapy with bacille Calmetle-Guérin (BCG) in patients with pre-existing squamous dysplasia of the bladder. 18 There have also been eight reports of cyclophosphamide-induced SCC of the bladder. 19 The association between SCC and long-standing leukoplakia and keratinizing squamous metaplasia has been speculated by some authors.…”

Section: Pathogenesismentioning

confidence: 98%

“…[20][21][22][23][24][25][26] Takai et al 22 noticed that the clinical behavior of pure SCC was similar to that of poorly differentiated TCC with an SCC component, a finding which may indicate a relationship between pure SCC and TCC with SCC in terms of histogenesis. Several studies have addressed the possible role of highrisk types (6,11,16,18,31, and 33) of human papilloma virus (HPV) in human bladder cancer, with conflicting results. 27,28 Sixteen SCCs of the urinary bladder were recently evaluated for the presence of high and low-risk HPV, with a sensitive detection system using non-isotopic in situ hybridization.…”

Section: Pathogenesismentioning

confidence: 99%

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Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management

El-Sebaie¹,

Zaghloul²,

Howard

et al. 2005

Int J Clin Oncol

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Squamous cell carcinoma of the urinary bladder, though uncommon in Europe and the United States, is the most common variety of bladder tumor in countries where urinary bilharziasis prevails. A great controversy still exists regarding its natural history and management. Here, we review the literature of bilharzial and nonbilharzial squamous cell carcinoma of the urinary bladder, focusing on large series. Our aim was to gather most of the published data about this disease entity, report it in a systematic comparative review, and attempt to identify the adverse features and variables behind its dismal outcome. The conclusions are that squamous cell carcinoma, whether bilharzial or nonbilharzial, has distinctive clinicopathological features, different from those of the transitional cell variety. These tumors usually present in advanced (muscle-invasive) stages. Pelvic nodal metastases are not common, and the incidence of distant metastases is less than that reported with transitional cell carcinoma. Local treatment, including cystectomy and adjunctive radiotherapy, is the most acceptable way of treating such tumors.

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Section: Pathogenesismentioning

confidence: 98%

Section: Pathogenesismentioning

confidence: 99%

Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management

El-Sebaie¹,

Zaghloul²,

Howard

et al. 2005

Int J Clin Oncol

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“…2 SCC of the bladder may also occur secondary to other chronic irritants, such as bacterial infections, foreign bodies (catheters, bladder calculi) and chronic bladder outlet obstruction. More rarely, there are reports of SCC of the bladder following intravesical Bacillus Calmette-Guéri (BCG), 3 systemic cyclophosphamide therapy, 4 and suprapubic catheters. 5 Lapides and colleagues introduced the concept of clean intermittent self-catheterization (ISC) in 1972 as a means of avoiding long-term catheterization or surgery.…”

Section: Introductionmentioning

confidence: 99%

Intermittent self-catheterization and the risk of squamous cell cancer of the bladder: An emerging clinical entity?

Casey

Cullen

Crotty

et al. 2013

CUAJ

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There are only 7 cases reported in the literature of squamous cell cancer of the bladder in patients performing intermittent selfcatheterization (ISC). We report on an eighth case, and the first case described in a patient with a Mitrofanoff continent appendicovesicostomy. A description of the case and review of the literature are presented. Risk factors for squamous cell cancer include recurrent urinary tract infections, keratinising squamous metaplasia (leukoplakia) and local mucosal trauma from intermittent selfcatheterization. There is no recognized or validated monitoring program for patients performing ISC who may also have these risk factors. Reasonable protocols may include regular urinary cytology and cystoscopy with random or targeted bladder biopsies. Squamous cell cancer may present late in this cohort of patients and is associated with a dismal prognosis. Can Urol Assoc J 2009;3(5):E51-E54 IntroductionSquamous cell cancer (SCC) of the bladder usually occurs secondary to bilharzia in the Middle East, Southeast Asia and South America, where schistosomiasis is endemic and accounts for 59% to 75% of cases. However, in western regions, SCC of the bladder usually constitutes only 1.2% to 4.5% of all bladder cancers, and these cases are usually secondary to prolonged indwelling catheters, especially in spinal cord-injured patients. This association with SCC has been documented for the last 30 years, 1 and a 10% incidence of bladder SCC in patients with an indwelling catheter for ≥10 years has been recognized. 2 SCC of the bladder may also occur secondary to other chronic irritants, such as bacterial infections, foreign bodies (catheters, bladder calculi) and chronic bladder outlet obstruction. More rarely, there are reports of SCC of the bladder following intravesical Bacillus Calmette-Guéri (BCG), 3 systemic cyclophosphamide therapy, 4 and suprapubic catheters. 5 Lapides and colleagues introduced the concept of clean intermittent self-catheterization (ISC) in 1972 as a means of avoiding long-term catheterization or surgery. 6 It was associated with low intravesical pressures, urinary bacterial wall translocation and thus infection, in a variety of neurogenic and non-neurogenic bladder disorders. This technique has been successful in a large number of adults and children on follow-up of more than 20 years. 7,8 Indeed, it is reported that clean ISC is more suitable than indwelling catheterization in patients who require long-term bladder drainage as a means of minimizing the histological changes that occur in the bladder mucosa that may predispose and lead to malignant transformation. 9,10 There are 7 reported cases in the published literature of SCC of the bladder due to a variety of reasons in patients using clean ISC (Table 1). [11][12][13][14] There may be a synergistic association of leukoplakia, persistent bacteriuria, direct catheter trauma and keratinizing squamous metaplasia with progression to SCC in these cases. Squamous metaplasia, which initially may be adaptive and protective, may also...

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“…Persistent bacteriuria and trauma may be the causes of squamous carcinoma. Extensive inflammation and squamous metaplasia play an important pathogenetic role and are often found in the distal urothelium of patients with SCC [9, 10, 11]. The role of human papilloma viruses in the pathogenesis of SCC remains uncertain [12].…”

Section: Introductionmentioning

confidence: 99%

Pure Squamous Cell Carcinoma of the Bladder in Western Countries

et al. 2000

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Squamous cell carcinoma of bladder after successful intravesical therapy with bacillus calmette-guérin

Cited by 13 publications

References 18 publications

Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management

Squamous cell carcinoma of the bilharzial and non-bilharzial urinary bladder: a review of etiological features, natural history, and management

Intermittent self-catheterization and the risk of squamous cell cancer of the bladder: An emerging clinical entity?

Pure Squamous Cell Carcinoma of the Bladder in Western Countries

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