Squamous Cell Carcinoma Arising in Long-standing Necrobiosis Lipoidica

Clement, Michele; Guy, Richard H.; Pembroke, A.C.

doi:10.1001/archderm.1985.01660010028008

Cited by 27 publications

(11 citation statements)

References 5 publications

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“…SCC is well known to arise in areas of chronic scarring and ulceration. Chronic scarring conditions include burn scars, vaccination sites, sinuses, stasis ulcers, cutaneous discoid lupus erythematosus, lupus vulgaris, and dystrophia epidermolysis bullosa 7,11 , 12,14 , 15 . However, it has rarely been described as arising from an area of NL.…”

Section: Discussionmentioning

confidence: 99%

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Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Lim¹,

Tschuchnigg²,

Lim

2006

J Cutan Pathol

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Section: Discussionmentioning

confidence: 99%

“…Ulceration may occur in the NL lesions; however, squamous cell carcinoma (SCC) has rarely been reported. To the author's knowledge, only nine cases have been reported so far 5–13 . We report another case which occurred in a patient with poorly controlled Type 1 diabetes mellitus and review the literature.…”

mentioning

confidence: 88%

Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Lim¹,

Tschuchnigg²,

Lim

2006

J Cutan Pathol

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“…These lesions are usually chronic and asymptomatic; however, ulcerated plaques have an increased risk of developing into squamous cell carcinoma 57,58 . Studies have proposed that NL develops in areas of the skin that suffer from neuropathy, explaining its occurrence on the legs 59,60 .…”

Section: Non‐infectious Manifestationsmentioning

confidence: 99%

Dermatologic manifestation of diabetes

Levy¹,

Zeichner²

2012

Journal of Diabetes

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With the rising incidence of diabetes mellitus (DM) in the US, it is of paramount importance that practitioners understand the complications of DM and how best to manage them. Diabetes affects every organ system and the skin is no exception. There are numerous cutaneous manifestations of DM that have similar etiologies and result from the same pathologic mechanisms as the internal complications of this disease state. In addition, skin manifestations may precede the diagnosis of diabetes. The present article reviews both the common and less common cutaneous manifestations of DM, including presenting lesions, pathogenesis, and management.

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“…The development of squamous cell carcinoma in areas of NL has been reported infrequently. To our knowledge seven tumours have been described in five patients 1–5 …”

Section: Introductionmentioning

confidence: 98%