Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Lim, Cathy; Tschuchnigg, Mark; Lim, Jake

doi:10.1111/j.1600-0560.2006.00487.x

Cited by 38 publications

(27 citation statements)

References 18 publications

(40 reference statements)

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“…7.11). [463][464][465][466][467][468] The simultaneous occurrence of necrobiosis lipoidica with granuloma annulare 469,470 and with sarcoidosis has been reported. 424 However, granuloma annulare and sarcoidosis have been reported in the same patient.…”

Section: Histopathologymentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Section: Histopathologymentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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“…9 Squamous cell carcinomas have occasionally been reported to complicate longstanding lesions. 7,10,20,21,22 …”

Section: Clinical Featuresmentioning

confidence: 99%

Necrobiosis lipoidica

George

Walton

2015

Br J Diabetes

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Necrobiosis lipoidica and granuloma annulare are granulomatous skin conditions that have been traditionally associated with diabetes mellitus, although recently the strength of association has been questioned. In the first section of this two-part article, we describe the suggested aetiology, clinical features, histology and treatment of necrobiosis lipoidica. It is found in 0.3% of patients with diabetes, but has also been reported with other systemic conditions. Clinically it appears as a waxy, atrophic, yellowish plaque with overlying telangiectasia and a brown border. Although usually asymptomatic, it may be extremely painful, especially if ulcerated. Squamous cell carcinoma has occasionally been reported with longstanding lesions. Treatment is often difficult: numerous topical and systemic agents have been employed, but evidence is limited to small case series and individual case reports. Br J Diabetes 2016;16:6-9

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“…In the necrobiotic type a necrobiosis of the collagen is present in the deep dermis with deposit of mucin and mixed inflammatory infiltrate consisting of lymphocytes, plasmocytes, histiocytes, fibroblasts, and epithelioid cells [16]. The chronic mechanical trauma may cause ulceration and scarring, which latter, as a complication, may contribute to the development of skin cancer [17]. Presently Mazzochi et al described the appearance of perforating necrobiosis lipoidica at the site of healed herpes zoster, classifying it as the “Wolf's isotopic response” [18].…”

Section: Discussionmentioning

confidence: 99%

Perforating Disseminated Necrobiosis Lipoidica Diabeticorum

Lozanova

Dourmishev

Vassileva

et al. 2013

Case Reports in Dermatological Medicine

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Perforating necrobiosis lipoidica is a very rare clinical variant which consists of degeneration and transepidermal elimination of the collagen with few cases reported in the literature. In two-thirds of the patients it associates with diabetes, with no relation with the glucose control. We present a 42-year-old female patient with a 7-year history of diabetes on insulin therapy, referred to our clinic with a 3-year history of multiple asymptomatic firm plaques disseminated on the upper and lower extremities. The clinical and histological findings proved the diagnosis of perforating necrobiosis lipoidica.

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Squamous cell carcinoma arising in an area of long‐standing necrobiosis lipoidica

Abstract: Clinicians should be aware of malignant transformation within a plaque of necrobiosis lipoidica. Early detection will allow conservative treatment.

Cited by 38 publications

References 18 publications

The granulomatous reaction pattern

The granulomatous reaction pattern

Necrobiosis lipoidica

Perforating Disseminated Necrobiosis Lipoidica Diabeticorum

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