Squamous cell carcinoma arising in an epidermal cyst

Sridevi, H B; Shariff, MH; Pai, Kaveri

doi:10.4103/0019-509x.176714

Cited by 5 publications

(6 citation statements)

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“…The incidence of SCC developing from an epidermal inclusion cyst has been estimated to range from 0.011 to 0.045% [ 1 ]. After a review of the literature, we found 41 well-documented cases of SCC arising from cutaneous epidermal inclusion cysts [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Our findings are summarized in Table 1 and Table 2 , which shows an increase in the number of reported cases of SCC arising from epidermal inclusion cysts since 2010.…”

Section: Discussionmentioning

confidence: 99%

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

et al. 2018

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Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining. Given the potential for variable presentation and low cost of hematoxylin and eosin analysis, we recommend a low threshold for a comprehensive pathological search for malignancy in excised cysts when appropriate.

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Section: Discussionmentioning

confidence: 99%

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

et al. 2018

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“…A recent review of the literature has found 41 well-documented cases of SCC arising from cutaneous epidermal cysts [ 2 ]. Most cases have occurred in the head and neck, and cases in trunk, limb, and gluteal tissues have also been reported [ 2 , 3 ]. In particular, perineal SCC arising from an epidermal cyst is extremely rare, and to date, three cases have been reported in the English literature.…”

Section: Discussionmentioning

confidence: 99%

“…However, cutaneous SCC arising from an epidermal cyst is quite rare [ 2 ]. The most common sites are the head and neck, and it has also been reported in the trunk, limb, and gluteal regions [ 3 ]. In particular, SCC arising from an epidermal cyst in the perineum is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

Perineal squamous cell carcinoma arising from an epidermal cyst: a case report

et al. 2018

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BackgroundEpidermal cysts and squamous cell carcinomas (SCCs) are common skin lesions. However, a malignant change in an epidermal cyst is very rare. The incidence of a malignant change from an epidermal cyst to cutaneous SCC is 0.011–0.045%. In particular, malignant transformation of an epidermal cyst in the perineum is extremely rare. To date, three cases have been reported in the English literature.Case presentationWe report a case of 51-year-old male with an approximately 15-cm perineal mass. This mass started to grow suddenly 4 months previously and caused great discomfort in the perineum due to the large size. The patient underwent excision of the mass with a negative margin. Histopathological analysis confirmed a microinvasive SCC arising from a proliferating epidermoid cyst.ConclusionsEven if benign tumors are suspected, a change in size, pain, ulceration, or discharge should indicate the need for surgical resection due to the possibility of a malignant change.

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“…However, they may become secondarily inflamed or infected or rarely develop malignancy [5]. There are very few reported cases of cutaneous squamous cell carcinoma (SCC) arising within epidermal cysts [10]. SCC within perineal epidermal cysts is even more rare [5].…”

Section: Discussionmentioning

confidence: 99%

“…Epidermal cysts are most commonly located on the head and neck but limbs, trunk and perineal region including scrotum and genitalia can also be affected [10]. An epidermal cyst may become ruptured depending upon the location and chances of external pressure.…”

Section: Discussionmentioning

confidence: 99%

A Case of Ruptured Perineal Epidermal Cyst

Gupta

Verma

Bansal

et al. 2020

Cureus

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Epidermal cysts are common skin lesions. They are usually seen in the chronic sun-exposed areas of the skin. They can get complicated by inflammation, infection, rupture, or malignancy. Epidermal cyst in the perineal region is rare. We report a case of an infected ruptured perineal epidermal cyst mimicking gluteal abscess. The patient was successfully treated by complete surgical excision. Histology revealed epidermal cyst with foreign body giant cell reaction and no evidence of malignancy.

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Squamous cell carcinoma arising in an epidermal cyst

Cited by 5 publications

References 0 publications

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

Perineal squamous cell carcinoma arising from an epidermal cyst: a case report

A Case of Ruptured Perineal Epidermal Cyst

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