Squamous Cell Carcinoma Antigen Immunoactivity is Normal in Maternal Serum but High and Increasing in Amniotic Fluid During Pregnancy

Dibbelt, L.; Knüppen, R.; Bobrowski, A

doi:10.1093/clinchem/38.10.2161

Cited by 3 publications

(1 citation statement)

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“…Among them, carcinoembryonic antigen (CEA) is the most widely used oncofetal tumour biomarker applied to clinical cancer diagnosis [26–27]. In addition, a range of other diagnostic oncofetal biomarkers have been identified including α‐fetoprotein [28–29], squamous cell antigen [30–31], survivin [32–33], cancer antigen 199 [34–35], prostate specific antigen [36–37], tissue polypeptide‐specific antigen [38–39] and human chorionic gonadotropin [40–41].…”

Section: Similarity In Protein Profilingmentioning

confidence: 99%

The relationship between early embryo development and tumourigenesis

Zhang

Feng

et al. 2010

J Cellular Molecular Medi

150

118

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With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin of tumour, and the similarities between early embryo development and tumourigenesis with respect to cell invasive behaviours, epigenetic regulation, gene expression, protein profiling and other important biological behaviours. Given an improved understanding of the relationship between early embryo development and tumourigenesis, now we have better and broader resources to attack cancer from the perspective of developmental biology and develop next generation of prognostic and therapeutic approaches for this devastating disease.

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Section: Similarity In Protein Profilingmentioning

confidence: 99%

The relationship between early embryo development and tumourigenesis

Zhang

Feng

et al. 2010

J Cellular Molecular Medi

150

118

View full text Add to dashboard Cite

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Tumor Markers In Biological Fluids Associated With Pregnancy

Sarandakou

Protonotariou

Rizos

2007

Critical Reviews in Clinical Laboratory Sciences

129

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Proteins that are expressed by both malignant and healthy fetal tissues are recognized as oncofetal. These antigens are associated with cell proliferation and differentiation and are produced in high concentrations in pregnancy and malignancy. Their biological role in malignancy is the suppression of the host's immune system, while in pregnancy they affect the maternal immune response, generating maternal tolerance toward the embryo. This review describes the levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), squamous cell carcinoma antigen (SCC), cancer antigen 15-3 (CA 15-3), mucin-like carcinoma-associated antigen (MCA), tissue polypeptide-specific antigen (TPS), carbohydrate antigen 19-9 (CA 19-9), and prostate-specific antigen (PSA) in maternal serum (MS), umbilical cord serum (UC), and amniotic fluid (AF) and outlines their roles in the assessment of pregnancy and malignancy. All antigens studied, except CA 15-3, are oncofetal. The presence of considerable concentrations of AFP, hCG, CEA, CA125, SCC, MCA, TPS, CA 19-9, and PSA in AF during pregnancy may be attributed to their involvement in biological functions associated with fetal development, differentiation, and maturation. MS CEA, CA 15-3, and CA 19-9, in contrast to all the others, are not influenced significantly by pregnancy and thus remain reliable tumor markers in monitoring malignancy in pregnant patients.

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