Serum Carcinoembryonic Antigen, Cancer Antigen 125, Cancer Antigen 15-3, Squamous Cell Carcinoma, and Tumor-associated Trypsin Inhibitor Concentrations during Healthy Pregnancy

Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study

“…This post‐delivery peak has been confirmed by some authors but not by others . However, some authors observed stable CA‐125 values from weeks 6–9 through weeks 35–40, although the range was broad .…”

“…The benefits of CA‐125 measurements during pregnancy have been offset by increased levels at both the early and late gestational ages, which is most likely due to hormonal regulation . Although some gestational age‐specific reference intervals for CA‐125 have been reported , most studies have not fulfilled the International Federation of Clinical Chemistry (IFCC) recommendation of a minimum sample size of 120 for the calculation of reference intervals . We report gestational age‐specific reference intervals for CA‐125 in women during pregnancy, at vaginal delivery, at acute or elective cesarean section, and in the early postpartum period.…”

A cross‐sectional study of tumor markers during normal and high‐risk pregnancies

“…Schlageter et al [14] evaluated serum samples from 12 healthy pregnant women at 6–40 weeks of amenorrhea for CEA, CA125, CA15‐3, SCC antigen, and tumor‐associated trypsin inhibitor. The tumor makers were mostly within the normal range, although values of tumor‐associated trypsin inhibitor and SCC antigen occasionally rose above the normal range, mostly during the last few months of pregnancy.…”

Can we trust tumour markers in pregnancy after breast cancer? A case of elevated CA 15-3 in the third trimester of pregnancy normalising after delivery

“…In some studies, CA 15-3 concentrations were significantly lower in non-pregnant women compared to those who were pregnant. The levels increased significantly with the progress of pregnancy even if they rarely went above cut-off values [10][11][12]. Cheli et al [13] evaluated maternal serum levels of four different tumour-associated antigens during the three trimesters of pregnancy in 90 healthy women.…”