Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy

Preis, Eduard; Baghdan, Elias; Agel, Michael R.; Anders, Thomas; Pourasghar, Marcel; Schneider, Marc; Bakowsky, Udo

doi:10.1016/j.ejpb.2019.07.023

Cited by 37 publications

(19 citation statements)

References 50 publications

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“…For this, adaptogenic herbs from the traditional system of medicine like Ayurvedic and Unani may be useful as rational formulation. Nano-spray suspension coated with a stable polymer and suspending agents along-with receptor-ligand could stabilize the entrapped Phyto-pharmacological agents like curcumin-nano-formulation ( Preis et al ., 2019 ; Taki et al ., 2016 ) for longer duration avoiding the pharmacokinetic failure. The application of nano-spray might be useful also to contain the infection for spreading further, when mild to moderate symptoms would arise by augmenting the cell surface receptor activation ( Furin and TMPRSS2 ).…”

Section: Discussionmentioning

confidence: 99%

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

et al. 2021

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Currently, novel coronavirus disease (Covid-19) outbreak creates global panic across the continents, as people from almost all countries and territories have been affected by this highly contagious viral disease. The scenario is deteriorating due to lack of proper & specific target-oriented pharmacologically safe prophylactic agents or drugs, and or any effective vaccine. drug development is urgently required to back in the normalcy in the community and to combat this pandemic. Thus, we have proposed two novel drug targets, Furin and TMPRSS2, as Covid-19 treatment strategy. We have highlighted this target-oriented novel drug delivery strategy, based on their pathophysiological implication on SARS-CoV-2 infection, as evident from earlier SARS-CoV-1, MERS, and influenza virus infection via host cell entry, priming, fusion, and endocytosis. An earlier study suggested that Furin and TMPRSS2 knockout mice had reduced level of viral load and a lower degree of organ damage such as the lung. The present study thus highlights the promise of some selected novel and potential anti-viral Phytopharmaceutical that bind to Furin and TMPRSS2 as target. As, few of them had shown promising anti-viral response in both preclinical and clinical study with acceptable therapeutic safety-index. Hence, this strategy may limit life-threatening Covid-19 infection and its mortality rate through nano-suspension based intra-nasal or oral nebulizer spray, to treat mild to moderate SARS-COV-2 infection, when Furin and TMPRSS2 receptor may initiate to express and activate for processing the virus to cause cellular infection by replication within the host cell.

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Section: Discussionmentioning

confidence: 99%

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

et al. 2021

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“…This plays an important role in membrane integrity and thus the ability to successfully deliver the active ingredient. Curcumin was chosen as it is a commonly used photosensitizer with a well-known impact [ 14 , 17 , 30 ]. Additionally, the suitability of two different nebulisation techniques, vibrating-mesh and air-jet, was tested and compared for the nebulisation of liposomes in small amounts.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

et al. 2021

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Lung cancer is one of the most common causes for a high number of cancer related mortalities worldwide. Therefore, it is important to improve the therapy by finding new targets and developing convenient therapies. One of these novel non-invasive strategies is the combination of pulmonary delivered tetraether liposomes and photodynamic therapy. In this study, liposomal model formulations containing the photosensitiser curcumin were nebulised via two different technologies, vibrating-mesh nebulisation and air-jet nebulisation, and compared with each other. Particle size and ζ-potential of the liposomes were investigated using dynamic light scattering and laser Doppler anemometry, respectively. Furthermore, atomic force microscopy and transmission electron microscopy were used to determine the morphological characteristics. Using a twin glass impinger, suitable aerodynamic properties were observed, with the fine particle fraction of the aerosols being ≤62.7 ± 1.6%. In vitro irradiation experiments on lung carcinoma cells (A549) revealed an excellent cytotoxic response of the nebulised liposomes in which the stabilisation of the lipid bilayer was the determining factor. Internalisation of nebulised curcumin-loaded liposomes was visualised utilising confocal laser scanning microscopy. Based on these results, the pulmonary application of curcumin-loaded tetraether liposomes can be considered as a promising approach for the photodynamic therapy against lung cancer.

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“…Since nanoparticles exhibited mechanisms leading to higher permeability by directly interacting with the bacterial cell wall and disrupting its three-dimensional organization, thereby increasing the uptake of photosensitizer (curcumin), and enhancing the aPDT efficacy. [16] . Pourhajibagher M et al indicated the antibacterial properties of nano-curcumin (nCur) reinforced with aPDT.…”

Section: Dear Editormentioning

confidence: 99%

Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

Law¹,

Leung

2021

Photodiagnosis and Photodynamic Therapy

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Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy

Cited by 37 publications

References 50 publications

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes

Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

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