Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

Law, Siukan; Leung, Albert Wingnang; Xu, Chuanshan

doi:10.1016/j.pdpdt.2021.102543

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…These problems of curcumin and methylene blue could be overcome with the help of nanotechnology, which produces nanoscale curcumin or methylene blue; its physical specifications, chemical properties, and biological characteristics enable it to have great bioavailability, solubility, transport, and effectiveness [ 108 ]. Nanotechnology improves the characteristics of curcumin and endows it with the ability to target an infected area, as well as inhibit viral replications that prevent the TMPRSS2 from interacting with disintegrin metallopeptidase domain 17 (ADAM17) to give a high level of ACE2 expression, causing lung inflammation and pulmonary oedema [ 109 ].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review

Law,

Leung,

2023

Pharmaceuticals

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Coronavirus disease 19 (COVID-19) has occurred for more than four years, and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is a strain of coronavirus, which presents high rates of morbidity around the world. Up to the present date, there are no therapeutics that can avert this form of illness, and photodynamic therapy (PDT) may be an alternative approach against SARS-CoV-2. Curcumin and methylene blue have been approved and used in clinical practices as a photosensitizer in PDT for a long time with their anti-viral properties and for disinfection through photo-inactivated SARS-CoV-2. Previously, curcumin and methylene blue with antibacterial properties have been used against Gram-positive bacteria, Staphylococcus aureus (S. aureus), and Gram-negative bacteria, Escherichia coli (E. coli), Enterococcus faecalis (E. faecalis), and Pseudomonas aeruginosa (P. aeruginosa). Methods: To conduct a literature review, nine electronic databases were researched, such as WanFang Data, PubMed, Science Direct, Scopus, Web of Science, Springer Link, SciFinder, and China National Knowledge Infrastructure (CNKI), without any regard to language constraints. In vitro and in vivo studies were included that evaluated the effect of PDT mediated via curcumin or methylene blue to combat bacteria and SARS-CoV-2. All eligible studies were analyzed and summarized in this review. Results: Curcumin and methylene blue inhibited the replication of SARS-CoV-2. The reactive oxygen species (ROS) are generated during the treatment of PDT with curcumin and methylene blue to prevent the attachment of SARS-CoV-2 on the ACE2 receptor and damage to the nucleic acids either DNA or RNA. It also modulates pro-inflammatory cytokines and attenuates the clotting effects of the host response. Conclusion: The photodynamic action of curcumin and methylene blue provides a possible approach against bacteria and SARS-CoV-2 infection because they act as non-toxic photosensitizers in PDT with an antibacterial effect, anti-viral properties, and disinfection functions.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review

Law,

Leung,

2023

Pharmaceuticals

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“…Besides, nanotechnology also assists TCM in photodynamic therapy (PDT) against SARS-CoV-2 after improving its bioavailability, such as curcumin [8]; Curcumin-loaded nanocarriers for increasing their bioavailability and therapeutic efficiency, which is an antiviral agent for the treatment of SARS-CoV-2 [9].…”

Section: Research Progressmentioning

confidence: 99%

A Short Commentary of Nanotechnology on Traditional Chinese Medicine

2022

J Nanotechnol Nanomaterials

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Traditional Chinese medicines (TCM) have many bioactive ingredients or parts, but there are still some limitations for medical field application, such as solubility and absorptivity in the human body. Nanotechnology is an effective way to enhance its bioavailability. How do we incorporate traditional Chinese medicines (TCM) with nanotechnology? This short commentary discusses the background of nanotechnology and its research progress with TCM as well as the future aspects.

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Could nanotechnology assist traditional Chinese medicine (TCM) in photodynamic therapy (PDT) against SARS-CoV-2?

Cited by 2 publications

References 18 publications

Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review

Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review

A Short Commentary of Nanotechnology on Traditional Chinese Medicine

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