Spontaneous Tumor Lysis Syndrome in Renal Cell Carcinoma: A Case Report

Norberg, Scott M.; Oros, Michelle; Birkenbach, Mark; Bilušić, Marijo

doi:10.1016/j.clgc.2014.04.007

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…To our knowledge, there was only one STLS case associated with kidney cancer reported. 8 But in that case, the patient had a larger renal mass (more than 10 cm), extensive necrosis and metastasis to lymph nodes, mesentery, adrenals, pleura, left bronchus, liver, and bones. On the contrary, our patient had a smaller mass without metastasis (stage T3a).…”

Section: Discussionmentioning

confidence: 87%

“…Risk factors for spontaneous cell lysis in solid tumors include cell chemo sensitivity, proliferation rate, large masses (especially if >10 cm), presence of liver and bone metastasis, extensive necrosis, high serum lactic dehydrogenase, and high serum uric acid levels and CKD. 3,8 Reduced renal function leads to hyperuricemia and crystal precipitation in renal tubules due to decreased uric acid clearance. Nephrotoxic agents like non-steroidal anti-inflammatory drugs, antibiotics, contrast, and drugs that interfere with uric acid excretion (thiazide diuretics, acetylsalicylic acid) should be avoided.…”

Section: Discussionmentioning

confidence: 99%

“…3,6,7 In renal cancer, there is only one report of STLS in metastatic disease. 8 We present here the first STLS case in a non-metastatic renal clear cell carcinoma.…”

Section: Introductionmentioning

confidence: 93%

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Spontaneous clinical tumor lysis syndrome in solid renal tumor: first case report in non-metastatic renal carcinoma

César

Nunes

Hazin

et al. 2020

Journal of Onco-Nephrology

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Spontaneous tumor lysis syndrome is a rare emergency in onco-nephrology that results from extensive cancer cell lysis independent of antitumoral therapy. It is common among hematological tumors and can be rarely seen with solid tumors. In medical literature, there is only one case report with spontaneous tumor lysis syndrome in renal cell carcinoma and it was associated with metastases. To the best of our knowledge, this is the first report of spontaneous tumor lysis syndrome in non-metastatic renal cell carcinoma.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Spontaneous clinical tumor lysis syndrome in solid renal tumor: first case report in non-metastatic renal carcinoma

César

Nunes

Hazin

et al. 2020

Journal of Onco-Nephrology

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“…The literature search identified 1440 unique results, where 47 articles met the inclusion criteria with a total of 807 patients included in the data analysis ( Figure 1 ). 1 , 10 , 11 , 13 , 15 , 18 – 60 Demographics, presenting features, treatment, and survival information were compiled for those patients with known status. The majority of patients were male (75.5%), and the mean age at diagnosis of RCC spine metastasis was 56.7 years.…”

Section: Resultsmentioning

confidence: 99%

The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment

Goodwin

Ahmed

Boone

et al. 2017

Global Spine Journal

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Study Design:Systematic review.Objectives:The objective of this systematic review was to answer 2 key questions: (1) What is the clinical presentation and probability of symptomatic improvement following treatment for patients with renal cell carcinoma (RCC) of the spine? (2) What is the overall survival of patients diagnosed with spinal metastases from RCC?Methods:A literature review was performed to identify articles that reported on survival, clinical outcomes, and/or prognostic factors in the RCC population with spinal metastases from 1986 to 2016.Results:Forty-eight articles (807 patients) were included. The Fuhrman Nuclear Grade has been significantly associated with survival in previous studies but was underpowered in the current study. The Memorial Sloan-Kettering Cancer Center Score (MSKCC/Motzer) was also underpowered in the current study. From the time of spinal metastasis, the mean and median survival for patients with previously diagnosed primary RCC was 8.75 and 11.7 months, respectively, whereas synchronously diagnosed patients (primary RCC and spinal metastasis) had a mean and median survival of 6.75 and 11 months, respectively. Patients with a “low” (0-8), “intermediate” (9-11), or “high” (12-15) revised Tokuhashi score at initial presentation had a median survival of 5.4, 11.7, and 32.9 months, respectively.Conclusion:Patients with either a synchronous or latent diagnosis of RCC survived greater than 6 months from the time of presentation. Initial Furhman grade, Tokuhashi score, and MSKCC/Motzer can be useful tools in informing patient-specific prognosis for those with metastatic RCC of the spine.

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“…Given the aforementioned risk factors, prevention of AKI is essential, therefore volume expansion with oral or intravenous fluids is paramount [ 12 , 13 , 37 ]. It is also prudent to avoid nephrotoxins such as non-steroidal anti-inflammatory drugs, iodinated contrast and vasoconstrictive medications [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Tumor Lysis Syndrome in Small-Cell Lung Cancer: A Rare Complication!

et al. 2015

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Tumor lysis syndrome (TLS) is a life-threatening condition which consists of a constellation of electrolyte imbalances, acute renal failure, seizure, and arrhythmias. It is most commonly seen with hematologic malignancies after the initiation of chemotherapy. However, it can also occur spontaneously, prior to treatment with cytotoxic agents. TLS has been rarely described with non-hematologic solid tumors, and it is even more uncommon to have spontaneous tumor lysis syndrome (STLS) in solid tumors. To our knowledge, only two cases of STLS in small-cell lung cancer (SCLC) were reported in the literature. Herein, we present the case of a patient with metastatic SCLC who developed STLS. Our case highlights that in the setting of metastatic solid tumors, STLS must be in the differential diagnosis, to allow prompt initiation of prophylaxis and treatment.

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Spontaneous Tumor Lysis Syndrome in Renal Cell Carcinoma: A Case Report

Cited by 14 publications

References 18 publications

Spontaneous clinical tumor lysis syndrome in solid renal tumor: first case report in non-metastatic renal carcinoma

Spontaneous clinical tumor lysis syndrome in solid renal tumor: first case report in non-metastatic renal carcinoma

The Challenges of Renal Cell Carcinoma Metastatic to the Spine: A Systematic Review of Survival and Treatment

Spontaneous Tumor Lysis Syndrome in Small-Cell Lung Cancer: A Rare Complication!

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