Spontaneous Tumor Lysis Syndrome in Small-Cell Lung Cancer: A Rare Complication!

Weerasinghe, Chanudi; Zaarour, Mazen; Arnaout, Sami; Garcia, Gwenalyn; Dhar, Meekoo

doi:10.14740/wjon946w

Cited by 14 publications

(12 citation statements)

References 46 publications

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“…All eight published patients of STLS in SCLC are summarized in Table 2 . [ 8 9 10 11 12 13 14 ] Seven of those patients had multiple liver metastases. The median age was 67 years (range: 53–73), and the median LDH was 1196 U/L (range: 399–3350) on presentation.…”

Section: Discussionmentioning

confidence: 99%

A case of spontaneous tumor lysis syndrome in extensive-stage small-cell lung cancer: A rare oncologic emergency

Alan¹,

Alan²

2020

Turk J Emerg Med

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Tumor lysis syndrome (TLS) is an oncologic emergency. It generally occurs after chemotherapy but sometimes develops spontaneously in hematologic malignancy, such as leukemia. TLS is a rare phenomenon in patients with solid tumors, particularly when it develops spontaneously. Here, we present a case of spontaneous TLS (STLS) in a patient with small-cell lung cancer (SCLC). We report a case of STLS in a 59-year-old male patient who presented with dyspnea and oliguria. Clinicians should suspect TLS in patients with malignancy, who demonstrate the classic electrolyte abnormalities of TLS even if not receiving treatment such as chemotherapy or radiotherapy.

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Section: Discussionmentioning

confidence: 99%

A case of spontaneous tumor lysis syndrome in extensive-stage small-cell lung cancer: A rare oncologic emergency

Alan¹,

Alan²

2020

Turk J Emerg Med

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“…Although spontaneous TLS is more common in hematological malignancies, it rarely develops in solid tumors. Small cell lung cancer, advance gastric cancer, endometrium cancer, hepatocellular carcinoma, colon carcinoma and over cancer from spontaneously TLS solid tumors have been described [7][8][9][10] .…”

Section: Resultsmentioning

confidence: 99%

Assessment of tumor lysis syndrome cases

Hüzmelí¹

2019

Cumhuriyet Medical Journal

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Tumor lysis syndrome (TLS) is a clinical picture that occurs with the rapid destruction of tumor cells and with life-threatening metabolic disorders. The aim of our study is to evaluate the etiologic causes, diagnosis and treatment of TLS cases. Method: The study was conducted between January 2015 and December 2017 in Kahramanmaras Necip Fazıl city Hospital. A total of 32 patients diagnosed with TLS were included in the study. Laboratory values of patients were scanned (blood urea nitrogen, creatinine, potassium, phosphorus, calcium, serum uric acid, lactate dehydrogenase) and diagnoses, chemotherapy and treatments were noted. Results: Of the 32 patients who were included in the study, 17 were male and 15 were female. The average age of the patients was found as 62,06 ± 12,10 (35-86) years. Hematologic malignancy was detected in the etiology of 11 of the TLS cases and solid tumor was detected in 21 of the TLS cases. A total of 12 (37.5%) patients had spontaneous TLS (5 in haematological malignancy and 7 in solid tumor). Hyperpotassaemia 50%, hypocalcaemia 46.9%, hyperphosphatemia, hyperuricemia and acute kidney damage was present in all patients. Mortality rate was found as 40.6%. Conclusions: In our study, spontaneous TLS was detected at a high rate. In addition, the mortality rate was also high. Early diagnosis and urgent treatment should be planned to avoid mortalities.

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“…Although rare, STLS in solid tumors seems to be associated with high mortality. In a literature review of the case reports of STLS in solid tumors, 17 out of 26 cases resulted in mortality [10]. The exact incidence and mortality of STLS in solid tumors is uncertain, owing to the lack of larger studies.…”

Section: Discussionmentioning

confidence: 99%

“…Spontaneous tumor lysis syndrome (SLTS) can occur without any preceding therapeutic interventions, which has been reported in hematologic and solid tumors [5]. To our knowledge, there are reported cases of STLS in small-cell carcinoma, but all were small-cell lung cancers [6–10]. Here, we would like to report the first case of STLS in small cell neuroendocrine carcinoma of unknown origin.…”

Section: Introductionmentioning

confidence: 93%

Spontaneous Tumor Lysis Syndrome Secondary to Small-Cell Neuroendocrine Carcinoma of Unknown Origin: A Rare Case Report and Literature Review

Myint

Butt

Alrifai

et al. 2019

Case Reports in Oncological Medicine

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Spontaneous tumor lysis syndrome (STLS), in the absence of prior chemo or radiation therapy, is rare with solid tumors. Here, we present a case of STLS secondary to a small-cell neuroendocrine tumor of unknown origin in a 66-year-old female patient who presented with abdominal discomfort. Computed tomography (CT) abdomen showed a large tumor mass with peritoneal metastasis, and she developed renal failure from STLS, resulting in the need for hemodialysis. Due to the progressive deterioration and the comorbidities, she opted for comfort care. Timely recognition and intervention of STLS is critical. Further studies evaluating STLS in solid tumor patients are recommended.

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Spontaneous Tumor Lysis Syndrome in Small-Cell Lung Cancer: A Rare Complication!

Cited by 14 publications

References 46 publications

A case of spontaneous tumor lysis syndrome in extensive-stage small-cell lung cancer: A rare oncologic emergency

A case of spontaneous tumor lysis syndrome in extensive-stage small-cell lung cancer: A rare oncologic emergency

Assessment of tumor lysis syndrome cases

Spontaneous Tumor Lysis Syndrome Secondary to Small-Cell Neuroendocrine Carcinoma of Unknown Origin: A Rare Case Report and Literature Review

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