Spontaneous Pneumomediastinum Associated with COVID-19 Pneumonia

Mimouni, Hamza; Diyas, Soufiane; Ouachaou, Jamal; Laaribi, Ilyass; Oujidi, Younes; Merbouh, Manal; Bkiyer, Houssam; Housni, Brahim

doi:10.1155/2020/4969486

Cited by 14 publications

(14 citation statements)

References 10 publications

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“…The exact mechanism of SP in non-ventilated patients remains unknown. However, the Macklin effect has been proposed as a possible etiology [3] owing to the SARS-CoV-2 propensity to damage type 2 pneumocytes [4]. The Macklin effect starts with alveolar rupture secondary to direct alveolar injury, leading to air leaking and dissection along the bronchovascular sheaths and eventually spreading of air within the mediastinum [5].…”

Section: Discussionmentioning

confidence: 99%

“…The air-leak can also spread to the fascial planes of the neck and chest leading to subcutaneous emphysema, which was also a manifestation in our patient. The most common symptom of pneumomediastinum is acute retrosternal chest pain [4] and should warrant early alert to rule out this dreaded complication in patients with suspected or confirmed COVID-19. However, our patient did not complain of retrosternal chest pain.…”

Section: Discussionmentioning

confidence: 99%

“…They also noted that there was no statistical difference in clinical severity in those with and without pneumomediastinum. Mimouni et al and Mohan et al [4,8] described cases of a 65-year-old male and a 49-year-old male, respectively, who deteriorated while being inpatient, and later a confirmed diagnosis of spontaneous pneumomediastinum was made with further imaging. Lastly, Volpi and colleagues described three severe cases of COVID-19 infection who required mechanical ventilation but later made full recovery and were discharged [9].…”

Section: Discussionmentioning

confidence: 99%

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The Macklin Effect in COVID-19

Iqbal¹,

Malik²,

Chaudhry³

2021

Cureus

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From the mere outlook of the ongoing pandemic, coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) seems to target mainly the respiratory system, but more evolving evidence has advocated its multi-organ involvement. While various complications have been reported in coronavirus disease 2019 (COVID-19) patients, spontaneous pneumomediastinum (SP) remains an uncommon complication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Macklin Effect in COVID-19

Iqbal¹,

Malik²,

Chaudhry³

2021

Cureus

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“…Oxygen therapy has been described to increase the resorption of free air in the mediastinum secondary to a higher nitrogen concentration. Continued treatment for COVID-19 is also essential as the virus may continue to damage type II pneumocytes in the lungs and subsequently damage alveolar membranes [11].…”

Section: Discussionmentioning

confidence: 99%

Isolated Spontaneous Pneumomediastinum in COVID-19 Patients: Case Series and Review of the Literature

Chen¹,

Roth²,

Thomas³

et al. 2021

J Med Imaging Case Rep

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While isolated spontaneous pneumomediastinum (SPM) is not commonly associated with viral respiratory infections, several cases of isolated SPM in the context of coronavirus disease 2019 (COVID-19) have emerged. Isolated SPM remains seldom presented in the current literature. We will present the clinical presentation and hospital course of isolated SPM in four patients hospitalized with COVID-19 who were not on mechanical ventilation. We will also review all cases from the current literature and compare these cases for similarities and possible patterns that may help elucidate risk factors for developing SPM. Increased use of high-flow oxygen in COVID-19 management may be a potential contributing factor to the SPM development. Isolated SPM can be an indicator of disease severity and worse prognosis.

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“…Recently, COVID-19 infection is confronted with this complication, which can further deteriorate the patient. The current literature search yields scarce case reports of this complication and one research by Eperjesiova et al reported a 0.72% incidence of spontaneous air leak in COVID-19 cases (Table1)[2][3][4][5][6][7].…”

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confidence: 99%

Spontaneous Pneumomediastinum in COVID-19 Pneumonia

Jesrani

Gupta

Kumar

et al. 2021

Cureus

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Spontaneous pneumomediastinum (SPM) is the collection of air within the mediastinal cavity, which is commonly described in the literature for mechanical ventilation and perforation of hollow viscera. Coronavirus disease 2019 (COVID-19) is a rare but salient etiology of this complication in the current pandemic. Here, we are narrating a case of a 46-year-old male, in whom COVID-19 pneumonia was complicated by SPM. The complication was identified on chest computed tomography (CT) and was managed conservatively, leading to a favorable outcome. SPM has undemanding management, but timely identification and appropriate treatment institution are crucial in this milieu. A literature search revealed similar cases of SPM in COVID-19 with different outcomes and the important ones are included in this report.

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Spontaneous Pneumomediastinum Associated with COVID-19 Pneumonia

Cited by 14 publications

References 10 publications

The Macklin Effect in COVID-19

The Macklin Effect in COVID-19

Isolated Spontaneous Pneumomediastinum in COVID-19 Patients: Case Series and Review of the Literature

Spontaneous Pneumomediastinum in COVID-19 Pneumonia

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