Spontaneous occurrence and experimental induction of leiomyoma of the ventral ligament of the oviduct of the hen

Anjum, A. D.; Payne, L. N.; Appleby, E. C.

doi:10.1016/s0034-5288(18)30962-7

Cited by 22 publications

(18 citation statements)

References 11 publications

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“…The frequently observed spontaneous tumours of the unknown aetiology in domestic fowls are leiomyoma of the ventral ligament (VL) of the oviduct [1,2] . These tumours are capsulated, round, solid masses and grow as solitary within VL of the oviduct [3,4] .…”

Section: Introductionmentioning

confidence: 99%

“…These tumours are capsulated, round, solid masses and grow as solitary within VL of the oviduct [3,4] . They are benign and consist of smooth muscle fibers located in a fibrous stroma [1] . Leiomyomas of the oviduct VL commonly arise after the end of a laying period [5] .…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that there is an association between the number of eggs produced in a laying period and the incidence of leiomyomas [4] . The prevalence of these tumours varied from 0% to 60% [1] . Although most genital organ leiomyomas in laying hens develop from the oviduct VL, occasional oviduct leiomyomas can also be seen [2] .…”

Section: Introductionmentioning

confidence: 99%

“…Oestrogen and progesterone hormones were suggested to have etiological importance on the tumourogenesis of the oviduct magnum region adenomas, oviduct adenocarcinomas and leiomyomas of the oviduct VL [1,5] . However, no such tumours could experimentally be induced in chicks by administration of only oestrogen or progesterone [1] .…”

Section: Introductionmentioning

confidence: 99%

“…However, no such tumours could experimentally be induced in chicks by administration of only oestrogen or progesterone [1] . On the other hand, concurrent i.m.…”

Section: Introductionmentioning

confidence: 99%

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Leiomyomas of Oviduct and Its Ventral Ligament of Hens: Immunohistochemical Evaluation and the Plasma Concentration Levels of 17 β-Oestradiol and Progesterone

Tunca¹,

Özkul²,

Salmanoğlu³

et al. 2014

Kafkas Univ Vet Fak Derg

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SummaryLeiomyoma's of the oviduct and its ventral ligament (VL) are common tumours of the domestic fowl which develop after the end of the first laying season. In the present study, macroscopic, microscopic, and immunohistochemical features of the leiomyomas of the reproductive tract and their prevalence were investigated in commercial laying hens. In 60-90 weeks old commercial laying hens, toward the end of the first laying period, the incidence of genital tract leiomyomas were determined as 10.43%. Of these, 95.81% were developed from oviduct VL and 4.19% were oviduct leiomyomas. These tumours were firm, round to oval and microscopically well-circumscribed, consisting of monomorphic spindle cells. In immunohistochemical examination with α-smooth muscle actin, desmin and vimentin, all tumours were found positive with these markers. To investigate the aetiological importance for tumourogenesis, the plasma concentrations of 17 β-oestradiol and progesterone levels were determined. Concentrations of 17 β-oestradiol and progesterone were higher in hens with tumours than that of non-tumour control animals. The results suggested that there was an association between the levels of 17 β-oestradiol and progesterone and the leiomyomas of genital tract in hens. Keywords: Leiomyomas of hens' oviduct, Incidence, Immunohistochemical evaluation, 17 β-oestradiol and Progesteron levels Yumurtacı Tavuklarda Ovidukt Ventral Ligamenti Leiomyomları:İmmunohistokimyasal İnceleme ve Plazma 17 β-Östradiol ve Progesteron Düzeyleri ÖzetOvidukt ve ovidukt ventral ligamenti (VL)nin leiomiyomları, ilk yumurtlama periyodunu tamamlayan yumurtacı tavuklarda oldukça sık karşılaşılan tümörlerdir. Çalışmada, ticari olarak yetiştirilen yumurtacı tavukların reprodüktif sistemlerinde gelişen leiomiyomların sıklığı ve bu tümörlerin makroskobik, mikroskobik ve immunohistokimyasal özellikleri değerlendirildi. İlk yumurtalama periyodunu tamamlamış, 60-90 haftalık yaşta, ticari yumurtacı tavuklarda, reprodüktif sistem leiomiyomlarının insidensi %10.43 olarak saptandı. Saptanan leiomiyomların %95.81'inin ovidukttun ventral ligamentinde, %4.19'un oviduktta yerleştiği belirlendi. Makroskobik olarak sert kıvamlı ve yuvarlak-oval şekilli olan bu tümörlerin mikroskobik incelemesinde iyi sınırlandırılmış mekik şeklindeki hücrelerden oluştuğu belirlendi. İmmunohistokimyasal incelemede, tüm tümörlerin α-smooth muscle actin, desmin ve vimentin primer antikorları ile pozitif reaksiyon verdikleri belirlendi. 17 β-östradiol ve progesteronun tümörogenezisteki etiyolojik öneminin değerlendirilmesi amacıyla plazma konsantrasyonları belirlendi. Tümör tespit edilen yumurtacı tavukların plazma 17 β-östradiol ve progesteron düzeyleri kontrol gruplarındaki yumurtacı tavuklardan anlamlı derecede yüksekti. Elde edilen bu sonuçlar ile, yumurtacı tavukların reprodüktif sistemlerinde sıklıkla ortaya çıkan leiomiyomların gelişiminin, plazma 17 β-östradiol ve progesteron düzeyleri ile ilişkili olduğu görüldü.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, no such tumours could experimentally be induced in chicks by administration of only oestrogen or progesterone [1] . On the other hand, concurrent i.m.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations