Spontaneous abortion rate and advanced maternal age: consequences for prenatal diagnosis

Cohen–Overbeek, Titia E.; Hop, Wim C. J.; Ouden, M.E.M. Den; Pijpers, L.; Jahoda, M; Wladimiroff, J. W.

doi:10.1016/0140-6736(90)91528-i

Cited by 38 publications

(20 citation statements)

References 13 publications

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“…A study that diagnosed pregnancy with daily urine specimens estimated a rate of 22 per cent for early spontaneous abortions that would not normally be noticed and a total rate of 31 per cent, including those happening later in pregnancy [69]. Most studies of spontaneous abortion start from the point where the mother is clearly known to be pregnant; they indicate a rate of 1-2% in young women rising to 7-10% in women over 35 [70,71]. In a study of 31-36 year-old Australian women, the total rate of spontaneous abortion was 25 per cent [72].…”

Section: The Range Of Issues (A) Medically Significant Genetic Variationmentioning

confidence: 99%

Evolutionary medicine: its scope, interest and potential

2012

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This review is aimed at readers seeking an introductory overview, teaching courses and interested in visionary ideas. It first describes the range of topics covered by evolutionary medicine, which include human genetic variation, mismatches to modernity, reproductive medicine, degenerative disease, hostpathogen interactions and insights from comparisons with other species. It then discusses priorities for translational research, basic research and health management. Its conclusions are that evolutionary thinking should not displace other approaches to medical science, such as molecular medicine and cell and developmental biology, but that evolutionary insights can combine with and complement established approaches to reduce suffering and save lives. Because we are on the cusp of so much new research and innovative insights, it is hard to estimate how much impact evolutionary thinking will have on medicine, but it is already clear that its potential is enormous.

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Section: The Range Of Issues (A) Medically Significant Genetic Variationmentioning

confidence: 99%

Evolutionary medicine: its scope, interest and potential

2012

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“…Fetal bradycardia and fetal tachycardia are associated with a high rate of miscarriage [24]. Yagel et al [9] demonstrated better correlation between FHR and CRL rather than gestational age.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chorionic Villus Sampling on Fetal Heart Rate

Akhlaghpoor¹,

Hosseinipoor²

2005

Fetal Diagn Ther

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Objective: Fetal heart rate (FHR) variation during chorionic villus sampling (CVS) is a controversial topic. Limited studies have been published on this subject. Our study intended to evaluate the effects of CVS on the FHR. Method: One hundred and sixty-five patients undergoing first-trimester elective CVS for prenatal diagnosis of β-thalassemia were entered into a prospective study. M-mode FHR was obtained before and immediately after CVS in the patients. Potentially confounding variables also recorded included: gestational age, number of needle passes and placental location. Results: FHR values before and after CVS were compared using the paired t test and showed no statistically significant differences by 95% confidence. No differences were found in data analyzing gestational age, number of needle passes or placental location. Conclusion: We were unable to detect any significant change in FHR after performing CVS. It seems that FHR is generally not altered by CVS.

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“…Entretanto, este percentual não tem sido confirmado por outros autores 4,9,13 , inclusive por este trabalho. Everett 4 refere que mulheres com antecedente de abortamento não apresentam um risco significativamente maior de uma segunda perda fetal consecutiva.…”

Section: Abortamentounclassified

Achados Ultra-Sonográficos em Pacientes com Ameaça de Abortamento no Primeiro Trimestre da Gestação

Watanabe

Brizot

Pereira

et al. 2000

Rev. Bras. Ginecol. Obstet.

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IntroduçãoA ameaça de abortamento é definida como a presença de sangramento vaginal com colo do útero impérvio ao exame clínico, sendo complicação relativamente freqüente que ocorre em cerca de 16 a 25% das gestações reconhecidas [1][2][3] . Apesar da possibilidade deste sangramento estar relacionado a causas vaginais ou cervicais, o abortamento constitui a principal preocupação do casal, levando na maioria das vezes à procura do seu médico.Após episódio de sangramento vaginal, a inviabilidade da gestação é observada em cerca de 50% dos casos a despeito das medidas terapêuticas adotadas 2,4,5 . O exame ultra-sonográfico tem sido empregado como método diagnóstico capaz de diferenciar as gestações viáveis das inviáveis. Anteriormente ao advento desta tecnologia, adotava-se para todos os casos conduta expectante, aguardando-se a possibilidade da ocorrência clínica do abortamento espontâneo para se intervir 5 . Quando, por meio do exame ultra-sonográfi-co, é identificada a inviabilidade da gestação, vá-rias são as possibilidades diagnósticas: abortamento completo, abortamento incompleto, abortamento retido, gestação anembrionada, gestação ectópica e doença trofoblástica gestacional. A identificação destes casos permite conduta atuante por parte do obstetra, reduzindo os riscos de sangramento e infecção 5 . Nos casos em que é diagnosti-

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Spontaneous abortion rate and advanced maternal age: consequences for prenatal diagnosis

Cited by 38 publications

References 13 publications

Evolutionary medicine: its scope, interest and potential

Evolutionary medicine: its scope, interest and potential

The Effect of Chorionic Villus Sampling on Fetal Heart Rate

Achados Ultra-Sonográficos em Pacientes com Ameaça de Abortamento no Primeiro Trimestre da Gestação

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