The Effect of Chorionic Villus Sampling on Fetal Heart Rate

Akhlaghpoor, Shahram; Hosseinipoor, Taraneh

doi:10.1159/000082434

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…However, in our study the rates for single insertion are 73% (720/986) for the control group and 82.1% (46/56) for cases, and so are lower than expected. The reason, as previously described by Akhlaghpoor and Hosseinipoor [23] , is that our referral genetic laboratories request more villi for medicolegal issues. At most of the second or third passes more villi are taken.…”

Section: Discussionmentioning

confidence: 86%

Safety of Chorionic Villus Sampling in the Presence of Asymptomatic Subchorionic Hematoma

Akhlaghpoor¹,

Tomasian²

2007

Fetal Diagn Ther

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Objective: According to our knowledge the safety of chorionic villus sampling (CVS) has not been studied in the presence of subchorionic hematoma (SCH). Our study aimed to evaluate the effects of CVS on the procedure-related fetal loss rate in patients with SCH. Method: Fifty-six patients with asymptomatic SCH (cases) and 986 controls in whom there was no hematoma underwent elective CVS for a prenatal diagnosis of β-thalassemia and were entered into a prospective study. Mean gestational age (±SD) at diagnosis for the case and control groups were 11.07 weeks (±0.95, range 10–13 weeks) and 11.51 weeks (±1.04, range 10–13 weeks), respectively. Procedural fetal loss rates were evaluated in these groups after follow-up until 28 weeks of gestation. Results: The average hematoma volume (±SD) was 1.83 ml (±1.57, range 0.3–10.0 ml). Post-CVS early fetal loss was seen in 3.57% (2/56) of patients in the case group and 1.62% (16/986) of patients in the control group. Late fetal loss (up to the 28th week) in the case and control groups was 8.16% (4/49) and 3.76% (29/771), respectively. Post-CVS early fetal loss was seen in 2.44% (1/41) of patients with small-sized SCH (<20% of gestational sac circumference) and in 6.67% (1/15) of patients with medium-sized SCH (20–50% of gestational sac circumference). Comparison of procedure-related early and late fetal loss in the case and control groups using Fisher’s exact test demonstrated no statistically significant difference (p value = 0.252, p value = 0.128). Difference in CVS-related early fetal loss in small- and medium-sized hematoma groups (6.67 vs. 2.44%) was not significant either (p value = 0.468). Conclusion: We were unable to detect any statistically significant difference in fetal loss rate after performing CVS in patients with SCH in comparison to the control group. However, it seems that fetal loss rate may be higher in the presence of medium-sized (20–50% of gestational sac circumference) SCH and further cases are necessary to evaluate the safety of doing CVS in this group.

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Section: Discussionmentioning

confidence: 86%

Safety of Chorionic Villus Sampling in the Presence of Asymptomatic Subchorionic Hematoma

Akhlaghpoor¹,

Tomasian²

2007

Fetal Diagn Ther

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Current awareness in prenatal diagnosis

2005

Prenat. Diagn.

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Chorionic villus sampling for beta-thalassemia: the first report of experience in Iran

Akhlaghpoor¹

2006

Prenat. Diagn.

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CVS is a safe and effective method for prenatal diagnosis of beta-thalassemia in countries with a high prevalence as in Iran. The overall complication rate is quite low and acceptable. Fortunately the recent acceptance of legal abortion with respect to Muslim rules has increased the effectiveness of the procedure and made great advances in its application in Iran. Correspondingly, social knowledge has also improved but still there is a gap between the population at risk and the required prenatal diagnosis laboratories and sampling centers.

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The Effect of Chorionic Villus Sampling on Fetal Heart Rate

Cited by 4 publications

References 36 publications

Safety of Chorionic Villus Sampling in the Presence of Asymptomatic Subchorionic Hematoma

Safety of Chorionic Villus Sampling in the Presence of Asymptomatic Subchorionic Hematoma

Current awareness in prenatal diagnosis

Chorionic villus sampling for beta-thalassemia: the first report of experience in Iran

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