Objective: Fetal heart rate (FHR) variation during chorionic villus sampling (CVS) is a controversial topic. Limited studies have been published on this subject. Our study intended to evaluate the effects of CVS on the FHR. Method: One hundred and sixty-five patients undergoing first-trimester elective CVS for prenatal diagnosis of β-thalassemia were entered into a prospective study. M-mode FHR was obtained before and immediately after CVS in the patients. Potentially confounding variables also recorded included: gestational age, number of needle passes and placental location. Results: FHR values before and after CVS were compared using the paired t test and showed no statistically significant differences by 95% confidence. No differences were found in data analyzing gestational age, number of needle passes or placental location. Conclusion: We were unable to detect any significant change in FHR after performing CVS. It seems that FHR is generally not altered by CVS.
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