Splenic hemangiopericytoma and serosal cavernous hemangiomatosis of the adjacent colon

Abstract

A healthy 31-years-old man presented with a three-year history of abdominal discomfort. Radiological examinations revealed multifocal tumoral lesions in the spleen. The patient underwent splenectomy for differential diagnosis and treatment. During the operation, in addition to the splenic masses, there were also multiple millimetric purpuric-like lesions on the colonic serosal surfaces adjacent to the splenic hilus. One of them was excised. Histologic examination showed hemangiopericytoma of the spleen and cavernous hemangioma of the adjacent colon. This is the first report showing the close association of these two distinct lesions with vascular origin in the literature. Despite not having any apparent evidence, there may be a sequential relationship between the hemangiopericytoma of the spleen and cavernous hemangiomas.

Congenital occurrence of solitary infantile myofibromatosis of the spleen

“…Since the first report of such an origin, published in 1989, 6 patients in adulthood and a 10-year-old boy have been described in the literature [3,[10][11][12][13][14][15]. All 7 of these patients were diagnosed as hemangiopericytoma based on the histologic findings.…”

Hemangiopericytoma of the spleen

“…In a small number of patients, the tumor may secrete insulin, renin or other hormones with consequent typical symptoms of a functioning tumor such as hypoglycemia or hypertension, which usually regress with tumor resection, but may be associated with a higher risk of recurrence [20,23]. In other patients the splenic hemangiopericytoma can be associated with malformations such as arterio-venous fistulas of the gastric fundus, thus presenting with upper gastrointestinal hemorrhage [32] or with serosal cavernomas or hemangiomas of the colon [26]. These aspects reflect a general, congenital disposition to dysplasia and neoplastic evolution.…”

“…The ultrasonographic picture can be that of an abscess or a cyst if the tumor has evolved in such a direction [25,31]. At CT-scan the tumor usually is that of a non-homogeneous, solid, hypodense, hypervascular, and well-defined splenic mass [24,26,27,29,30], which is consistent with an angioma or other splenic tumors, metastases, sarcomas or hamartomas [22e24, 26,27,30]. If abscess or colliquation is present, the findings of the CT-scan are consistent with these conditions [25,31].…”

Primary Haemangiopericytoma in the Pelvic Cavity of a Dog

“…The pelvic cavity is also a very rare site for this tumour to develop. In humans, HHP are often found mostly in the lower extremities but they can also occur in the pelvic retroperitoneum or other sites including the spleen, bladder, prostate and spermatic cord (Baumgartner et al., 1976; Enzinger and Smith, 1976; Chen, 1987; Siemens et al., 1998; Torigoe et al., 2003; Kim et al., 2005; Yilmazlar et al., 2005).…”